Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan.
Schizophr Res. 2018 Dec;202:180-187. doi: 10.1016/j.schres.2018.07.009. Epub 2018 Jul 10.
Patients with schizophrenia show severe impairment in social function and have difficulty in their daily social life. Although a recent large-scale multicenter study revealed alterations in white matter microstructures, the association between these anatomical changes and social dysfunction in schizophrenia remains unknown. Therefore, we investigated the association between the white matter integrity of regions of interest and social function in schizophrenia. A total of 149 patients with schizophrenia and 602 healthy comparison subjects (HCS) underwent DTI and completed the Picture Arrangement subtest of the Wechsler Adult Intelligence Scale-Third Edition and the Finance subscale of the University of California, San Diego, Performance-Based Skills Assessment Brief, as social indices of interest. The fractional anisotropy (FA) in the anterior corona radiata and corpus callosum was significantly lower in patients than in HCS, and the radial diffusivity (RD) in the anterior corona radiata and corpus callosum was significantly higher in patients. The Picture Arrangement and Finance scores were both significantly impaired in patients. The effect of the FA of the right anterior corona radiata on the Finance score and the Picture Arrangement score, of the RD of the right anterior corona radiata on the Picture Arrangement score, and of the RD of the corpus callosum on the Picture Arrangement score were significant. In conclusion, our results confirmed the association between structural connectivity in the right frontal white matter and corpus callosum and social function in schizophrenia. These findings may provide a foundation for developing an intervention for functional recovery in schizophrenia.
精神分裂症患者的社会功能严重受损，日常生活困难。尽管最近一项大规模多中心研究揭示了精神分裂症患者白质微观结构的改变，但这些解剖结构变化与精神分裂症患者社会功能之间的关联仍不清楚。因此，我们调查了精神分裂症患者感兴趣区域的白质完整性与社会功能之间的关系。共有 149 名精神分裂症患者和 602 名健康对照组（HCS）接受了 DTI 检查，并完成了韦氏成人智力量表第三版的图片排列测验和加利福尼亚大学圣地亚哥分校的金融子量表，作为感兴趣的社会指标。与 HCS 相比，患者的前冠状辐射和胼胝体的各向异性分数（FA）明显降低，而前冠状辐射和胼胝体的辐射弥散度（RD）明显升高。患者的图片排列和金融评分均明显受损。右侧前冠状辐射的 FA 对金融评分和图片排列评分的影响，右侧前冠状辐射的 RD 对图片排列评分的影响，以及胼胝体的 RD 对图片排列评分的影响均有统计学意义。总之，我们的研究结果证实了右侧额白质和胼胝体的结构连接与精神分裂症患者社会功能之间的关联。这些发现可能为开发精神分裂症功能恢复的干预措施提供基础。
