Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.
Mental Health Department, Enna, Italy.
Anat Sci Int. 2023 Sep;98(4):473-481. doi: 10.1007/s12565-023-00730-w. Epub 2023 Jun 20.
Recent evidence has shown that the precuneus plays a role in the pathogenesis of schizophrenia. The precuneus is a structure of the parietal lobe's medial and posterior cortex, representing a central hub involved in multimodal integration processes. Although neglected for several years, the precuneus is highly complex and crucial for multimodal integration. It has extensive connections with different cerebral areas and is an interface between external stimuli and internal representations. In human evolution, the precuneus has increased in size and complexity, allowing the development of higher cognitive functions, such as visual-spatial ability, mental imagery, episodic memory, and other tasks involved in emotional processing and mentalization. This paper reviews the functions of the precuneus and discusses them concerning the psychopathological aspects of schizophrenia. The different neuronal circuits, such as the default mode network (DMN), in which the precuneus is involved and its alterations in the structure (grey matter) and the disconnection of pathways (white matter) are described.
最近的证据表明，楔前叶在精神分裂症的发病机制中起作用。楔前叶是顶叶内侧和后皮质的结构，代表一个涉及多模态整合过程的中央枢纽。尽管楔前叶多年来一直被忽视，但它非常复杂，对多模态整合至关重要。它与不同的大脑区域有广泛的联系，是外部刺激和内部表现之间的接口。在人类进化过程中，楔前叶的体积和复杂性增加，从而使更高的认知功能得以发展，如视觉空间能力、心理意象、情景记忆和其他涉及情感处理和心理化的任务。本文综述了楔前叶的功能，并讨论了它们与精神分裂症的心理病理学方面的关系。描述了不同的神经元回路，如默认模式网络（DMN），其中涉及楔前叶及其在结构（灰质）和通路中断（白质）中的改变。
