Hamanaka Gen, Ohtomo Ryo, Takase Hajime, Lok Josephine, Arai Ken
Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Neurosci Lett. 2018 Sep 25;684:175-180. doi: 10.1016/j.neulet.2018.07.016. Epub 2018 Jul 10.
White matter injury caused by acute or chronic neuropathologies is a major characteristic of many CNS diseases, and an effective treatment is still out of our reach. White matter damage is associated with the collapse of the axon-myelin complex and with blood-brain barrier (BBB) breakdown, which results in disruption of white matter function. While white matter damage cannot completely resolve spontaneously, some compensative responses may occur after the injury. Oligodendrocyte lineage cells perform critical functions in repairing damaged white matter. In this mini-review, we will focus on the reparative actions of the oligodendrocytes, and highlight the important role of oligodendrocyte lineage cells in brain recovery after injury.
急性或慢性神经病理学引起的白质损伤是许多中枢神经系统疾病的主要特征，而目前我们仍无法找到有效的治疗方法。白质损伤与轴突-髓鞘复合体的崩溃以及血脑屏障（BBB）的破坏有关，这会导致白质功能紊乱。虽然白质损伤无法完全自发修复，但损伤后可能会出现一些代偿性反应。少突胶质细胞系细胞在修复受损白质中发挥着关键作用。在本综述中，我们将重点关注少突胶质细胞的修复作用，并强调少突胶质细胞系细胞在脑损伤后恢复中的重要作用。
