缺氧诱导因子介导的肿瘤和免疫细胞代谢适应。
Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors.
机构信息
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):15-22. doi: 10.1016/j.bbcan.2018.07.002. Epub 2018 Jul 11.
Cancer cells are characterized by high metabolic demand. The substrates in demand include oxygen, glucose, glutamine and lipids. Oxygen serves as a key substrate in cellular metabolism and bioenergetics. Hypoxia or low oxygen abundance is a common feature of the tumor microenvironment that occurs due to an imbalance in supply and demand. Many of the metabolic responses to hypoxia in both cancer cells and stromal cells are orchestrated by hypoxia-inducible factors (HIFs). In this review we summarize our current understanding of how HIFs modulate the metabolism of hypoxic cancer cells and immune cells, and how altered metabolism plays a role in cancer progression.
癌细胞的特点是高代谢需求。需求的底物包括氧气、葡萄糖、谷氨酰胺和脂质。氧气是细胞代谢和生物能量的关键底物。缺氧或低氧丰度是肿瘤微环境的一个常见特征，是由于供需失衡引起的。缺氧诱导因子 (HIFs) 协调了癌细胞和基质细胞对缺氧的许多代谢反应。在这篇综述中，我们总结了我们目前对 HIF 如何调节缺氧癌细胞和免疫细胞代谢的理解，以及代谢改变如何在癌症进展中发挥作用。
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