Program in Cancer Research, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), CIBERONC, Barcelona, Spain.
Curr Opin Cell Biol. 2018 Dec;55:1-7. doi: 10.1016/j.ceb.2018.06.010. Epub 2018 Jul 10.
Notch is a well-conserved signaling pathway all through evolution that is crucial to specify different cell fates. Although there is a strong context dependent component in each decision, the basic mechanisms that originate from the interplay among ligands and receptors is greatly preserved. In this review we will cover the latest findings on the different mechanisms for Notch activation and signaling. The regulation of this pathway is essential to understand development, cell differentiation and disease.
Notch 是一条在整个进化过程中都被高度保守的信号通路，对细胞命运的特化至关重要。尽管在每个决策中都存在强烈的上下文依赖性成分，但源于配体和受体相互作用的基本机制却得到了很好的保留。在这篇综述中，我们将介绍 Notch 激活和信号转导的不同机制的最新发现。对该通路的调控对于理解发育、细胞分化和疾病至关重要。
