硝酰基脂肪酸的生成和代谢。
Nitro-fatty acid formation and metabolism.
机构信息
Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
CIBICI - CONICET, Departamento de Bioquímica Clínica Facultad de Ciencias Químicas, (U.N.C.), Haya de la Torre y Medina Allende Ciudad Universitaria, Córdoba C.P. N°: X5000HUA, Argentina.
出版信息
Nitric Oxide. 2018 Sep 1;79:38-44. doi: 10.1016/j.niox.2018.07.003. Epub 2018 Jul 10.
Abstract
Nitro-fatty acids (NO-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO-FA signaling, endogenous formation and metabolism is relatively unexplored. This review will cover what is currently known regarding the proposed mechanisms of NO-FA formation, dietary modulation of endogenous NO-FA levels, pathways of NO-FA metabolism and the detection of NO-FA and corresponding metabolites.
摘要
硝酰基脂肪酸（NO-FA）是氧化还原信号通路的多效调节剂。它们对炎症信号的影响已在细胞、动物和临床模型中进行了广泛研究，主要使用外源性给予的硝基油酸。虽然我们对 NO-FA 信号有了相当多的了解，但内源性的形成和代谢仍相对未知。这篇综述将涵盖目前已知的关于 NO-FA 形成的拟议机制、内源性 NO-FA 水平的饮食调节、NO-FA 代谢途径以及 NO-FA 和相应代谢物的检测。
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