Stumpf Janice L, Leja Noah, Ciarkowski Scott L, Salah Sharon, Schaeffler Kristen L
Department of Pharmacy Services, Michigan Medicine, Ann Arbor, MI, and University of Michigan College of Pharmacy, Ann Arbor, MI
Department of Pharmacy, St. Joseph Mercy Hospital, Ann Arbor, MI.
Am J Health Syst Pharm. 2018 Sep 15;75(18):1394-1398. doi: 10.2146/ajhp180085. Epub 2018 Jul 13.
The development of a compounded oral liquid medication formulary and subsequent implementation of revised standard formulations in a university health system are described.
A standard assessment form was developed to direct evaluation of published literature and current compounding resources for all oral liquid formulations prepared by health-system pharmacies. Specific variables reviewed included concentration, components, beyond-use dating, and storage recommendations. After their review and approval, revised formulations were typed into distinct templates that incorporated additional safety features. An online departmental repository was developed to house the revised formulations.
Modifications were made to 136 (78%) of the 175 compounded formulations reviewed. Changes in storage conditions and extension of beyond-use dating were the most common revisions in 77 (44%) and 42 (24%) of compounds, respectively. In addition, strawberry syrup was removed as a component of 38 (22%) formulations, reducing exposure of pediatric patients to red dye. Presentations were given at several forums to inform pharmacy staff of the goals of the project and details regarding implementation. In addition, e-mail communications were sent to share the online location of the updated formulations and compounding sheets. Nursing, medical, and pharmacy staff were notified of concentration changes through the pharmacy newsletter and e-mail.
A comprehensive review resulted in updates to over 75% of oral liquid medications prepared by pharmacies in a university health system. Revised formulations were made available through an online repository, ensuring consistency of compounding procedures with respect to concentrations, components, and storage requirements.
描述在大学健康系统中制定复方口服液体制剂配方集并随后实施修订后的标准配方的过程。
制定了一份标准评估表，用于指导对健康系统药房制备的所有口服液体制剂的已发表文献和当前配制资源进行评估。审查的具体变量包括浓度、成分、使用期限和储存建议。经审查和批准后，将修订后的配方录入包含额外安全特性的不同模板中。开发了一个在线部门知识库来存放修订后的配方。
在审查的175种复方制剂中，有136种（78%）进行了修改。储存条件的改变和使用期限的延长是最常见的修订，分别在77种（44%）和42种（24%）化合物中出现。此外，38种（22%）制剂中去除了草莓糖浆作为成分，减少了儿科患者接触红色染料的机会。在几个论坛上进行了介绍，向药房工作人员通报项目目标和实施细节。此外，还发送了电子邮件，分享更新配方和配制单的在线位置。通过药房通讯和电子邮件向护理、医疗和药房工作人员通报了浓度变化。
全面审查使大学健康系统药房制备的超过75%的口服液体制剂得到更新。修订后的配方通过在线知识库提供，确保了配制程序在浓度、成分和储存要求方面的一致性。
