Mettl3-Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells.
作者信息
Yao Qi Jason, Sang Lina, Lin Minghui, Yin Xiujuan, Dong Wenjie, Gong Yuping, Zhou Bo O
机构信息
State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.
Department of Hematology, West China Hospital, Sichuan University, 610041, Sichuan, China.
出版信息
Cell Res. 2018 Sep;28(9):952-954. doi: 10.1038/s41422-018-0062-2. Epub 2018 Jul 13.
Abstract
摘要
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本文引用的文献
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Promoter-bound METTL3 maintains myeloid leukaemia by mA-dependent translation control.与启动子结合的METTL3通过依赖于N6-甲基腺苷（mA）的翻译控制维持髓系白血病。
Nature. 2017 Dec 7;552(7683):126-131. doi: 10.1038/nature24678. Epub 2017 Nov 27.
2
The N-methyladenosine (mA)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.形成N-甲基腺苷（mA）的酶METTL3控制正常造血细胞和白血病细胞的髓系分化。
Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
3
Mettl3-/Mettl14-mediated mRNA N-methyladenosine modulates murine spermatogenesis.Mettl3-/Mettl14 介导的 mRNA N6-甲基腺苷修饰调节小鼠精子发生。
Cell Res. 2017 Oct;27(10):1216-1230. doi: 10.1038/cr.2017.117. Epub 2017 Sep 15.
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mA modulates haematopoietic stem and progenitor cell specification.mA 调节造血干细胞和祖细胞的分化。
Nature. 2017 Sep 14;549(7671):273-276. doi: 10.1038/nature23883. Epub 2017 Sep 6.
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Mettl3-mediated mA regulates spermatogonial differentiation and meiosis initiation.Mettl3 介导的 mA 调节精原细胞分化和减数分裂起始。
Cell Res. 2017 Sep;27(9):1100-1114. doi: 10.1038/cr.2017.100. Epub 2017 Aug 15.
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Nat Rev Mol Cell Biol. 2016 Oct;17(10):643-58. doi: 10.1038/nrm.2016.76. Epub 2016 Jul 13.
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Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.Mettl3和Mettl14甲基转移酶协同作用的结构基础
Mol Cell. 2016 Jul 21;63(2):306-317. doi: 10.1016/j.molcel.2016.05.041. Epub 2016 Jun 30.
8
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.METTL3-METTL14 复合物介导的 N(6)-腺苷甲基化的结构基础。
Nature. 2016 Jun 23;534(7608):575-8. doi: 10.1038/nature18298. Epub 2016 May 25.
9
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.哺乳动物 WTAP 是 RNA N6-甲基腺嘌呤甲基转移酶的调节亚基。
Cell Res. 2014 Feb;24(2):177-89. doi: 10.1038/cr.2014.3. Epub 2014 Jan 10.
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N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells.N6-甲基腺苷修饰使胚胎干细胞中的发育调控因子失稳。
Nat Cell Biol. 2014 Feb;16(2):191-8. doi: 10.1038/ncb2902. Epub 2014 Jan 7.
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