Lab for Clinical & Integrative Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA.
Department of Surgical Sciences, Section of Neurosurgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Sci Rep. 2018 Jul 13;8(1):10609. doi: 10.1038/s41598-018-29036-y.
Early and moderate Parkinson's disease patients seem to have attention dysfunctions manifested differentially in separate attention streams: top-down and bottom-up. With a focus on the neurophysiological underpinnings of such differences, this study evaluated source-localized regional activity and functional connectivity of regions in the top-down and bottom-up streams as well as any discordance between the two streams. Resting state electroencephalography was used for 36 Parkinson's disease patients and 36 healthy controls matched for age and gender. Parkinson's disease patients showed disproportionally higher bilateral gamma activity in the bottom-up stream and higher left alpha2 connectivity in the top-down stream when compared to age-matched controls. An additional cross-frequency coupling analysis showed that Parkinson's patients have higher alpha2-gamma coupling in the right posterior parietal cortex, which is part of the top-down stream. Higher coupling in this region was also associated with lower severity of motor symptoms in Parkinson's disease. This study provides evidence that in Parkinson's disease, the activity in gamma frequency band and connectivity in alpha2 frequency band is discordant between top-down and bottom-up attention streams.
早期和中度帕金森病患者似乎存在注意力功能障碍，这些障碍在自上而下和自下而上的不同注意力流中表现不同。本研究关注这种差异的神经生理学基础，评估了自上而下和自下而上流中区域的源定位局部活动和功能连接，以及两个流之间的任何不和谐。使用静息状态脑电图对 36 名帕金森病患者和 36 名年龄和性别匹配的健康对照者进行了评估。与年龄匹配的对照组相比，帕金森病患者在自下而上的流中表现出不成比例的更高的双侧伽马活动，而在自上而下的流中表现出更高的左侧阿尔法 2 连通性。额外的跨频耦合分析表明，帕金森病患者在右后顶叶皮层的阿尔法 2-伽马耦合较高，该区域是自上而下流的一部分。该区域的更高耦合也与帕金森病患者运动症状的严重程度较低相关。本研究提供的证据表明，在帕金森病中，自上而下和自下而上的注意力流之间存在伽马频带活动和阿尔法 2 频带连接的不和谐。
