• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Association of HLA-DQA1 gene polymorphisms with the risk of children primary nephrotic syndrome in Chinese population.中国人群中HLA - DQA1基因多态性与儿童原发性肾病综合征风险的关联
J Clin Lab Anal. 2019 Jan;33(1):e22623. doi: 10.1002/jcla.22623. Epub 2018 Jul 13.
2
HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.HLA-DQA1和PLCG2是儿童期起病的类固醇敏感性肾病综合征的候选风险基因座。
J Am Soc Nephrol. 2015 Jul;26(7):1701-10. doi: 10.1681/ASN.2014030247. Epub 2014 Oct 27.
3
HLA-DQA1 and APOL1 as Risk Loci for Childhood-Onset Steroid-Sensitive and Steroid-Resistant Nephrotic Syndrome.HLA-DQA1 和 APOL1 作为儿童发病的激素敏感性和激素抵抗性肾病综合征的风险基因座。
Am J Kidney Dis. 2018 Mar;71(3):399-406. doi: 10.1053/j.ajkd.2017.10.013. Epub 2017 Dec 23.
4
Interaction between PLA2R1 and HLA-DQA1 variants contributes to the increased genetic susceptibility to membranous nephropathy in Western China.PLA2R1 与 HLA-DQA1 变异体的相互作用导致中国西部地区膜性肾病遗传易感性增加。
Nephrology (Carlton). 2019 Sep;24(9):919-925. doi: 10.1111/nep.13536. Epub 2019 Apr 29.
5
Association of HLA-DQA1 (rs9272219) with susceptibility to rheumatoid arthritis in a Han Chinese population.汉族人群中HLA-DQA1（rs9272219）与类风湿关节炎易感性的关联
Int J Clin Exp Pathol. 2014 Oct 15;7(11):8155-8. eCollection 2014.
6
PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians.南亚人原发性膜性肾病中的PLA2R抗体、肾小球PLA2R沉积物以及PLA2R1和HLA - DQA1基因的变异
Nephrol Dial Transplant. 2016 Sep;31(9):1486-93. doi: 10.1093/ndt/gfv399. Epub 2015 Dec 15.
7
Variants in the Promoter Region of were Associated with Idiopathic Membranous Nephropathy in a Chinese Han Population.在中国汉族人群中，[基因名称]启动子区域的变异与特发性膜性肾病相关。 （注：原文中“of”后面缺少具体基因名称）
Chin Med J (Engl). 2017 Jul 20;130(14):1677-1682. doi: 10.4103/0366-6999.209884.
8
Analysis of PLA2R1 and HLA-DQA1 sequence variants in Japanese patients with idiopathic and secondary membranous nephropathy.日本特发性和继发性膜性肾病患者中PLA2R1和HLA - DQA1序列变异的分析。
Clin Exp Nephrol. 2018 Apr;22(2):275-282. doi: 10.1007/s10157-017-1471-0. Epub 2017 Aug 28.
9
Associations between m-type phospholipase A2 receptor,human leukocyte antigen gene polymorphisms and idiopathic membranous nephropathy.M 型磷脂酶 A2 受体、人类白细胞抗原基因多态性与特发性膜性肾病的相关性研究。
Bioengineered. 2021 Dec;12(1):8833-8844. doi: 10.1080/21655979.2021.1987080.
10
, , and Alleles Associated with Acute Tubulointerstitial Nephritis in a Chinese Population: A Single-Center Cohort Study.中国人急性肾小管间质性肾炎相关的 、 等位基因：一项单中心队列研究。
J Immunol. 2018 Jul 15;201(2):423-431. doi: 10.4049/jimmunol.1800237. Epub 2018 Jun 1.

本文引用的文献

1
HLA-DQA1 and APOL1 as Risk Loci for Childhood-Onset Steroid-Sensitive and Steroid-Resistant Nephrotic Syndrome.HLA-DQA1 和 APOL1 作为儿童发病的激素敏感性和激素抵抗性肾病综合征的风险基因座。
Am J Kidney Dis. 2018 Mar;71(3):399-406. doi: 10.1053/j.ajkd.2017.10.013. Epub 2017 Dec 23.
2
Identifying key regulating miRNAs in hepatocellular carcinomas by an omics' method.通过组学方法鉴定肝细胞癌中的关键调控微小RNA
Oncotarget. 2017 Oct 17;8(61):103919-103930. doi: 10.18632/oncotarget.21865. eCollection 2017 Nov 28.
3
Driver genes in non-small cell lung cancer: Characteristics, detection methods, and targeted therapies.非小细胞肺癌中的驱动基因：特征、检测方法及靶向治疗
Oncotarget. 2017 Apr 10;8(34):57680-57692. doi: 10.18632/oncotarget.17016. eCollection 2017 Aug 22.
4
Precision medicine for hepatocellular carcinoma: driver mutations and targeted therapy.肝细胞癌的精准医学：驱动突变与靶向治疗
Oncotarget. 2017 Jun 6;8(33):55715-55730. doi: 10.18632/oncotarget.18382. eCollection 2017 Aug 15.
5
Combination therapeutics in complex diseases.复杂疾病中的联合疗法。
J Cell Mol Med. 2016 Dec;20(12):2231-2240. doi: 10.1111/jcmm.12930. Epub 2016 Sep 7.
6
Bioinformatics and Microarray Analysis of miRNAs in Aged Female Mice Model Implied New Molecular Mechanisms for Impaired Fracture Healing.老年雌性小鼠模型中miRNA的生物信息学与微阵列分析揭示了骨折愈合受损的新分子机制
Int J Mol Sci. 2016 Aug 3;17(8):1260. doi: 10.3390/ijms17081260.
7
Impact of HLA in cord blood transplantation outcomes.脐血移植结局中 HLA 的影响。
HLA. 2016 Jun;87(6):413-21. doi: 10.1111/tan.12792. Epub 2016 Apr 6.
8
CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425.CTNNA3是一种肝细胞癌中的肿瘤抑制因子，且受到miR - 425的抑制。
Oncotarget. 2016 Feb 16;7(7):8078-89. doi: 10.18632/oncotarget.6978.
9
A case of primary immune deficiency presenting with nephrotic syndrome.一例以肾病综合征为表现的原发性免疫缺陷病。
NDT Plus. 2010 Oct;3(5):456-8. doi: 10.1093/ndtplus/sfq083. Epub 2010 May 11.
10
The Role of HLA-G Molecule and HLA-G Gene Polymorphisms in Tumors, Viral Hepatitis, and Parasitic Diseases.HLA-G分子及HLA-G基因多态性在肿瘤、病毒性肝炎和寄生虫病中的作用
Front Immunol. 2015 Feb 2;6:9. doi: 10.3389/fimmu.2015.00009. eCollection 2015.

中国人群中HLA - DQA1基因多态性与儿童原发性肾病综合征风险的关联

Association of HLA-DQA1 gene polymorphisms with the risk of children primary nephrotic syndrome in Chinese population.

作者信息

Zhu Bingbing, Zhang Ruifeng, Yang Huandan, Yuan Tingting, Lv Juan, Peng Qianqian, Tian Lijun

机构信息

Xuzhou Children's Hospital, Xuzhou, Jiangsu, China.

出版信息

J Clin Lab Anal. 2019 Jan;33(1):e22623. doi: 10.1002/jcla.22623. Epub 2018 Jul 13.

DOI:10.1002/jcla.22623
PMID:30006974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6430441/
Abstract

BACKGROUND

The association between gene polymorphisms and the risk of primary nephrotic syndrome (PNS) is uncovering recently. This study aims to investigate the relationship between single nucleotide polymorphisms (SNPs) on HLA-DQA1 gene and the risk of PNS.

METHODS

In this study, we genotyped eight single nucleotide polymorphisms (SNPs) in the HLA-DQA1 gene in 501 PNS patients and 532 healthy people in Chinese population. Then we analyzed associations of these SNPs with the clinical features in primary nephrotic syndrome of children in Chinese population.

RESULTS

Significant associations with PNS were found on missense SNP rs1129740 (GG vs AA, odds ratio (OR) = 1.987, 95% confidence interval (CI) = 1.468-2.652, P = 0.00177049) and rs1047992 (AA vs GG, OR = 1.857, 95% CI = 1.325-2.391, P = 1.1073E-10) of the HLA-DQA1 gene.

CONCLUSIONS

This work suggests SNPs of HLA-DQA1 are risk factors for PNS in Chinese population, which implies roles of immune response in the pathogenesis of PNS.

摘要

背景

基因多态性与原发性肾病综合征（PNS）风险之间的关联最近正在被揭示。本研究旨在探讨HLA - DQA1基因上的单核苷酸多态性（SNP）与PNS风险之间的关系。

方法

在本研究中，我们对中国人群中501例PNS患者和532名健康人的HLA - DQA1基因中的8个单核苷酸多态性（SNP）进行了基因分型。然后我们分析了这些SNP与中国人群儿童原发性肾病综合征临床特征之间的关联。

结果

在HLA - DQA1基因的错义SNP rs1129740（GG与AA相比，优势比（OR）= 1.987，95%置信区间（CI）= 1.468 - 2.652，P = 0.00177049）和rs1047992（AA与GG相比，OR = 1.857，95% CI = 1.325 - 2.391，P = 1.1073E - 10）中发现了与PNS的显著关联。

结论

这项工作表明HLA - DQA1的SNP是中国人群中PNS的危险因素，这意味着免疫反应在PNS发病机制中的作用。