Aydin Zeki, Gursu Meltem, Ozturk Savas, Kilicaslan Isın, Kazancioglu Rumeyza
Department of Nephrology , Haseki Training and Research Hospital , Istanbul , Turkey.
Department of Pathology, Istanbul Medical Faculty , Istanbul University , Istanbul , Turkey.
NDT Plus. 2010 Oct;3(5):456-8. doi: 10.1093/ndtplus/sfq083. Epub 2010 May 11.
Common variable immunodeficiency (CVID) is the most common form of severe antibody deficiency. The disorder is associated with a broad spectrum of clinical manifestations, including infections and chronic lung, gastrointestinal and autoimmune diseases. A 29-year-old female patient has had frequent sinopulmonary infections and gastroenteritis for the last 20 years and had been given broad-spectrum antibiotics for treatment. Immunoglobulin (Ig) levels were at undetectable levels. Renal biopsy was consistent with AA amyloidosis. She is now under follow-up with periodic intravenous Ig treatment without any infection during the last 10 months. CVID must be kept in mind in patients with recurrent sinopulmonary infections.
普通可变型免疫缺陷（CVID）是严重抗体缺陷最常见的形式。该病症与广泛的临床表现相关，包括感染以及慢性肺部、胃肠道和自身免疫性疾病。一名29岁女性患者在过去20年中频繁发生鼻窦肺部感染和肠胃炎，并接受了广谱抗生素治疗。免疫球蛋白（Ig）水平检测不到。肾活检符合AA型淀粉样变性。她目前正在接受定期静脉注射Ig治疗的随访，在过去10个月中未发生任何感染。对于反复发生鼻窦肺部感染的患者，必须考虑到CVID。
