Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical Collegec, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Environ Int. 2018 Oct;119:407-412. doi: 10.1016/j.envint.2018.07.009. Epub 2018 Jul 20.
Gestational weight gain (GWG) is increasingly reported to be associated with adverse birth outcomes. However, the effect of PM exposure during pregnancy on GWG is unknown.
We investigated the associations between the exposure to PM and GWGs during three pregnancy trimesters based on a prospective birth cohort.
Data were obtained from 2029 pregnant women who participated in a birth cohort between January 2013 and October 2014 in Wuhan, China. A spatial-temporal land use regression model was used to estimate the trimester and overall pregnancy exposures of PM of each pregnant woman. The relationships between PM exposure and GWG were estimated using linear mixed models.
The median value of GWG was 2.0 kg (interquartile range (IQR): 4.0) in the first trimester, 6.5 kg (IQR: 3.5) in the second trimester, and 7.0 kg (IQR: 3.5) in the third trimester, respectively. The exposure to PM was peaked in the first trimester (median concentration: 117.3 μg/m (IQR: 71.9)). After adjustment for potential confounders, each 10 μg/m increase in PM was consistently associated with increases in GWG in overall pregnancy (0.14 kg, 95% confidence interval (CI): 0.12, 0.17), the first (0.15 kg, 95%CI: 0.12, 0.18), second (0.15 kg, 95%CI: 0.10, 0.19) and third trimester (0.13 kg, 95%CI: 0.09, 0.17). Further stratified analysis indicated that pregnant women who delivered in spring or summer gained more body weight associated with PM exposure.
This study provides evidence on the effect of exposure to PM on GWG and it is the first report on the importance of reducing the ambient PM in controlling of GWG in pregnant women.
越来越多的研究表明，孕期体重增加与不良分娩结局有关。然而，孕期 PM 暴露对 GWG 的影响尚不清楚。
我们基于前瞻性出生队列，研究了 PM 暴露与孕期三个阶段 GWG 的关系。
数据来自于 2013 年 1 月至 2014 年 10 月期间参加中国武汉出生队列的 2029 名孕妇。采用时空土地利用回归模型估计每位孕妇孕期各阶段的 PM 暴露情况。采用线性混合模型估计 PM 暴露与 GWG 的关系。
GWG 的中位数在孕早期、孕中期和孕晚期分别为 2.0kg（IQR：4.0）、6.5kg（IQR：3.5）和 7.0kg（IQR：3.5）。PM 暴露在孕早期达到峰值（中位数浓度：117.3μg/m（IQR：71.9））。调整潜在混杂因素后，PM 每增加 10μg/m，总体孕期 GWG 增加 0.14kg（95%置信区间：0.12，0.17）、孕早期增加 0.15kg（95%置信区间：0.12，0.18）、孕中期增加 0.15kg（95%置信区间：0.10，0.19）和孕晚期增加 0.13kg（95%置信区间：0.09，0.17）。进一步分层分析表明，春季或夏季分娩的孕妇与 PM 暴露相关的体重增加更多。
本研究为 PM 暴露对 GWG 的影响提供了证据，也是关于减少孕妇环境 PM 以控制 GWG 的重要性的首次报告。
