Donhuijsen K, Kroll M, Krause U
Dtsch Med Wochenschr. 1986 Jan 10;111(2):46-51. doi: 10.1055/s-2008-1068399.
Surgical specimens after excision of malignant fibrous histiocytomas from 41 patients were classified histologically according to subtype; semiquantitatively by cell content, mitosis count, necrosis tendency and cell polymorphism; and "subjective grading". There was no significant difference in survival time between storiform-pleomorphic and myxoid subtypes. The marked scatter in the storiform-pleomorphic subtype reflects the inhomogeneity of this group. Analysis of the individual semiquantitative criteria gave better results. Cases with many mitoses, many necroses, marked cell polymorphism and high cell content had significantly shorter survival times than those with less marked changes. "Subjective grading" was also of prognostic value. However, overlapping of prognostic factors and limitations due to tumour biology allow of only a rough orientating prediction based on histological assessment of malignancy grade.
对41例恶性纤维组织细胞瘤切除术后的手术标本进行组织学亚型分类；根据细胞含量、有丝分裂计数、坏死倾向和细胞多形性进行半定量分析；并进行“主观分级”。席纹状多形性亚型和黏液样亚型之间的生存时间无显著差异。席纹状多形性亚型中明显的离散性反映了该组的不均一性。对各个半定量标准的分析得出了更好的结果。有许多有丝分裂、许多坏死、明显细胞多形性和高细胞含量的病例，其生存时间明显短于变化不明显的病例。“主观分级”也具有预后价值。然而，由于肿瘤生物学特性导致的预后因素重叠和局限性，仅能基于恶性程度的组织学评估进行粗略的定向预测。
