簇细胞-ILC2 回路整合肠道防御和稳态。
The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis.
机构信息
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY 10032, USA.
出版信息
Cell. 2018 Jul 12;174(2):251-253. doi: 10.1016/j.cell.2018.06.037.
The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft cells sense succinate fermented by Tritrichomonas via GPR91 to drive the IL-25-ILC2-IL-13-dependent immune circuit and intestinal remodeling.
肠道对寄生虫感染的反应是由一个新建立的 2 型免疫回路介导的，该回路由肠道毛细胞和 2 型先天淋巴细胞 (ILC2) 组成。Schneider 等人发现，毛细胞通过 GPR91 感知 Tritrichomonas 发酵的琥珀酸，从而驱动 IL-25-ILC2-IL-13 依赖的免疫回路和肠道重塑。
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