Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Immunol. 2024 Jan 12;14:1266667. doi: 10.3389/fimmu.2023.1266667. eCollection 2023.
Intestinal tuft cells (TCs) are defined as chemosensory cells that can "taste" danger and induce immune responses. They play a critical role in gastrointestinal parasite invasion, inflammatory bowel diseases and high-fat diet-induced obesity. Intestinal IL-25, the unique product of TCs, is a key activator of type 2 immunity, especially to promote group 2 innate lymphoid cells (ILC2s) to secret IL-13. Then the IL-13 mainly promotes intestinal stem cell (ISCs) proliferation into TCs and goblet cells. This pathway formulates the circuit in the intestine. This paper focuses on the potential role of the intestinal TC, ILC2 and their circuit in obesity-induced intestinal damage, and discussion on further study and the potential therapeutic target in obesity.
肠簇细胞（TCs）被定义为能够“感知”危险并诱导免疫反应的化学感觉细胞。它们在胃肠道寄生虫入侵、炎症性肠病和高脂肪饮食诱导的肥胖中发挥着关键作用。肠道白介素 25（IL-25）是 TCs 的独特产物，是 2 型免疫的关键激活剂，特别是促进 2 型固有淋巴细胞（ILC2）分泌白介素 13（IL-13）。然后，IL-13 主要促进肠干细胞（ISCs）增殖为 TCs 和杯状细胞。该途径在肠道中形成了一个回路。本文重点介绍了肠道 TC、ILC2 及其回路在肥胖诱导的肠道损伤中的潜在作用，并讨论了进一步研究和肥胖潜在治疗靶点的问题。
