肥大细胞活化障碍的儿科表现

Pediatric Expression of Mast Cell Activation Disorders.

作者信息

Broesby-Olsen Sigurd, Carter Melody, Kjaer Henrik Fomsgaard, Mortz Charlotte Gotthard, Møller Michael Boe, Kristensen Thomas Kielsgaard, Bindslev-Jensen Carsten, Agertoft Lone

机构信息

Mastocytosis Centre Odense University Hospital (MastOUH), Søndre Boulevard 29, 5000 Odense C, Denmark; Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, Søndre Boulevard 29, 5000 Odense C, Denmark.

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Immunol Allergy Clin North Am. 2018 Aug;38(3):365-377. doi: 10.1016/j.iac.2018.04.009. Epub 2018 May 21.

DOI:10.1016/j.iac.2018.04.009

PMID:30007457

Abstract

Mast cell activation disorders is a term proposed to cover diseases and conditions related to activation of mast cells and effects of mast cell mediators. In its broadest sense, the term encompasses a wide range of diseases from allergic asthma to rhinoconjunctivitis, urticaria, food allergy, anaphylaxis, mastocytosis, and other conditions where MC activation is contributing to the pathogenesis. This article focuses on clinical presentations, challenges, and controversies in pediatric mastocytosis and gives an overview of current knowledge and areas in need of further research.

摘要

肥大细胞活化障碍是一个提出用于涵盖与肥大细胞活化及肥大细胞介质作用相关的疾病和病症的术语。从最广泛的意义上讲，该术语涵盖了从过敏性哮喘到鼻结膜炎、荨麻疹、食物过敏、过敏反应、肥大细胞增多症以及其他肥大细胞活化参与发病机制的多种疾病。本文重点关注儿童肥大细胞增多症的临床表现、挑战和争议，并概述当前的知识以及需要进一步研究的领域。