Sirtuin 1 与阿尔茨海默病：最新综述。

Sirtuin 1 and Alzheimer's disease: An up-to-date review.

机构信息

Division of Geriatric Neurology, Neurology Service, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS 90035-903, Brazil; School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90035-903, Brazil.

出版信息

Neuropeptides. 2018 Oct;71:54-60. doi: 10.1016/j.npep.2018.07.001. Epub 2018 Jul 9.

DOI:10.1016/j.npep.2018.07.001

PMID:30007474

Abstract

Sirtuins are NAD+-dependent enzymes that regulate a large number of cellular pathways and are related to aging and age-associated diseases. In recent years, the role of sirtuins in Alzheimer's disease (AD) has become increasingly apparent. Growing evidence demonstrates that sirtuin 1 (SIRT1) regulates many processes that go amiss in AD, such as: APP processing, neuroinflammation, neurodegeneration, and mitochondrial dysfunction. Here we review how SIRT1 affects AD and cognition, the main mechanisms in which SIRT1 is related to AD pathology, and its importance for the prevention and possible diagnosis of AD.

摘要

Sirtuins 是 NAD+-依赖性酶，可调节许多细胞途径，与衰老和与年龄相关的疾病有关。近年来，sirtuins 在阿尔茨海默病 (AD) 中的作用变得越来越明显。越来越多的证据表明，sirtuin 1 (SIRT1) 调节 AD 中出错的许多过程，如：APP 加工、神经炎症、神经退行性变和线粒体功能障碍。在这里，我们回顾 SIRT1 如何影响 AD 和认知，SIRT1 与 AD 病理相关的主要机制，以及它对 AD 的预防和可能诊断的重要性。