唑来膦酸治疗会使下颌骨易发生骨折吗？一项大鼠的影像学和生物力学研究。

Does zoledronate therapy make mandibular bone susceptible to fracture? A radiographical and biomechanical study in rats.

作者信息

Zandi Mohammad, Shokri Abbas, Mousavi Maryam, Rajaei Sanaz, Mohammad Gholi Mezerji Naser

机构信息

Department of Oral and Maxillofacial Surgery, Hamadan University of Medical Sciences, Hamadan, Iran; Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Department of Oral and Maxillofacial Radiology, Hamadan University of Medical Sciences, Hamadan, Iran.

出版信息

Injury. 2018 Oct;49(10):1746-1749. doi: 10.1016/j.injury.2018.07.006. Epub 2018 Jul 6.

DOI:10.1016/j.injury.2018.07.006

PMID:30007517

Abstract

INTRODUCTION

The aim of this study was to evaluate the effect of zoledronate therapy on susceptibility of mandibular bone to fracture in rats.

METHODS

Fifty rats were randomly allocated to two groups of 25 animals. The rats in group Z received monthly intravenous infusion of 0.06 mg/kg zoledronate for 6 months. The rats in the group C were injected with an equal volume of saline in the same manner. A month after the last zoledronate/saline administration, all 50 rats were euthanized. Using a cone beam computed tomography, the cortical thickness of inferior border of mandible and the mandibular bone mineral density were calculated, and using a three-point bending test, the peak load failure and the ultimate stress of mandibular bone were determined.

RESULTS

The mean mandibular inferior cortical bone thickness and the mean bone mineral density were significantly larger in zoledronate-treated rats (0.30 ± 0.02 mm and 1045.00 ± 185.79, respectively) compared to control rats (0.21 ± 0.01 mm and 878.66 ± 166.53, respectively). The peak load and the ultimate stress were lower in the zoledronate-treated hemimandibles (84.61 ± 33.62 N and 1.76 ± 0.72 MPa, respectively) compared to the control hemimandibles (98.36 ± 16.5 9 N and 2.03 ± 0.44 MPa, respectively).

CONCLUSION

Zoledronate therapy reduced the mechanical strength of the mandibles, implying an increased risk of mandibular fracture in rats.

摘要

引言

本研究旨在评估唑来膦酸治疗对大鼠下颌骨骨折易感性的影响。

方法

将50只大鼠随机分为两组，每组25只。Z组大鼠每月静脉输注0.06mg/kg唑来膦酸，持续6个月。C组大鼠以相同方式注射等量生理盐水。在最后一次给予唑来膦酸/生理盐水后的一个月，将所有50只大鼠安乐死。使用锥形束计算机断层扫描计算下颌骨下缘的皮质厚度和下颌骨骨密度，并通过三点弯曲试验确定下颌骨的峰值载荷破坏和极限应力。

结果

与对照大鼠（分别为0.21±0.01mm和878.66±166.53）相比，接受唑来膦酸治疗的大鼠的平均下颌骨下缘皮质骨厚度和平均骨密度显著更大（分别为0.30±0.02mm和1045.00±185.79）。与对照半下颌骨（分别为98.36±16.59N和2.03±0.44MPa）相比，接受唑来膦酸治疗的半下颌骨的峰值载荷和极限应力更低（分别为84.61±33.62N和1.76±0.72MPa）。