Department of Pharmaceutical and Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, PR China.
College of Chemistry and Environment Protection Engineering, Southwest Minzu University, Chengdu 610041, PR China.
Food Res Int. 2018 Sep;111:237-243. doi: 10.1016/j.foodres.2018.05.039. Epub 2018 May 21.
Consumers demand more alternatives of riskless antibacterial agents to prevent microbial contamination in food industry. Oxidized carbohydrate may be a potential option as new antibacterial agent. However, the relatively weak antibacterial property of oxidized carbohydrate is not satisfactory. In this paper, dialdehyde β-cyclodextrins with different oxidation degree were prepared by periodate oxidation and their antibacterial properties were systematically studied. The results showed that multi-aldehyde groups were successfully introduced into β-cyclodextrin molecules by periodate oxidation. The aqueous solubility and stability of dialdehyde β-cyclodextrins were improved as expected. It is interesting that dialdehyde β-cyclodextrins possessed outstanding antibacterial activity against both Gram-positive and Gram-negative bacteria. The minimal inhibitory concentrations against E. coli, S. aureus and B. subtilis reached 0.63, 1.25 and 0.63 mg/mL, respectively. Moreover, dialdehyde β-cyclodextrins effectively inhibited bacterial growth on the surface of apples. The results demonstrated that oxidized oligosaccharide with multi-aldehyde groups and good dispersibility in aqueous solution possessed satisfactory antibacterial activity, which can be used as new antibacterial agent in food industry.
消费者要求更多的无风险抗菌剂替代品来防止食品工业中的微生物污染。氧化碳水化合物可能是一种有潜力的新型抗菌剂。然而，氧化碳水化合物相对较弱的抗菌性能并不令人满意。本文通过高碘酸盐氧化法制备了不同氧化度的二醛-β-环糊精，并对其抗菌性能进行了系统研究。结果表明，高碘酸盐氧化成功地将多醛基引入β-环糊精分子中。二醛-β-环糊精的水溶性和稳定性得到了预期的提高。有趣的是，二醛-β-环糊精对革兰氏阳性菌和革兰氏阴性菌均具有优异的抗菌活性。对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌的最小抑菌浓度分别达到 0.63、1.25 和 0.63mg/mL。此外，二醛-β-环糊精能有效抑制苹果表面的细菌生长。结果表明，具有多醛基和良好水溶性的氧化低聚糖具有令人满意的抗菌活性，可作为食品工业中的新型抗菌剂。
