School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China.
Carbohydr Polym. 2018 Jul 15;192:118-125. doi: 10.1016/j.carbpol.2018.03.060. Epub 2018 Mar 20.
Dialdehyde-amyloses, dicarboxyl-amyloses and dialdehyde-carboxyl-amyloses with different oxidation levels were prepared and used to study the effects of aldehyde and carboxyl groups on the antibacterial activity of oxidized amyloses. The results showed that dicarboxyl-amyloses presented antibacterial activity through acidic pH effect produced by carboxyl groups, which was easily reduced or eliminated by adjusting pH. Dialdehyde-amyloses possessed a broad-spectrum antibacterial activity owing to the reactivity of aldehyde groups rather than acidic pH effect. Aldehyde would irreversibly damage bacterial cell wall and cytoplasmic membrane, resulting in decay and death of bacterial cells. It is interesting that the antibacterial properties of dialdehyde-carboxyl-amyloses were improved to some extent compared to dialdehyde-amyloses. The improvement of antibacterial effect of dialdehyde-carboxyl-amyloses may be due to the increasing dispersibility endowed by carboxyl groups, which could effectively enhance the interaction between dialdehyde-carboxyl-amyloses and bacteria. As a result, carboxyl group could act as a promising synergistic group against bacteria with aldehyde group.
制备了不同氧化程度的双醛淀粉、二羧基淀粉和双醛-羧基淀粉，并研究了醛基和羧基对氧化淀粉抗菌活性的影响。结果表明，二羧基淀粉通过羧基产生的酸性 pH 效应表现出抗菌活性，通过调节 pH 值很容易被还原或消除。双醛淀粉由于醛基的反应性而具有广谱抗菌活性，而不是酸性 pH 效应。醛基会不可逆地破坏细菌细胞壁和细胞质膜，导致细菌细胞的衰退和死亡。有趣的是，与双醛淀粉相比，双醛-羧基淀粉的抗菌性能在某种程度上有所提高。双醛-羧基淀粉抗菌效果的提高可能是由于羧基赋予的分散性增加，这可以有效地增强双醛-羧基淀粉与细菌之间的相互作用。因此，羧基可以作为一种有前途的协同基团，与醛基一起对抗细菌。
