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Compromise of α-Defensin Function in Liver Cirrhosis Facilitates the Toxic Relationship Between Gut Permeability and Endotoxemia.

作者信息

Kaliannan Kanakaraju

机构信息

Laboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA, 02129, USA.

出版信息

Dig Dis Sci. 2018 Oct;63(10):2492-2494. doi: 10.1007/s10620-018-5197-y.

DOI:10.1007/s10620-018-5197-y
PMID:30008088
Abstract
摘要

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Compromise of α-Defensin Function in Liver Cirrhosis Facilitates the Toxic Relationship Between Gut Permeability and Endotoxemia.肝硬化中α-防御素功能受损促进了肠道通透性与内毒素血症之间的有害关系。
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2
Expression of α-Defensins, CD20+ B-lymphocytes, and Intraepithelial CD3+ T-lymphocytes in the Intestinal Mucosa of Patients with Liver Cirrhosis: Emerging Mediators of Intestinal Barrier Function.肝硬化患者肠黏膜中α-防御素、CD20+B 淋巴细胞和上皮内 CD3+T 淋巴细胞的表达：肠屏障功能的新介质。
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Alpha-defensin increase in peripheral blood mononuclear cells from patients with hepatitis C virus chronic infection.丙型肝炎病毒慢性感染患者外周血单个核细胞中α-防御素增加。
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Multifaceted involvements of Paneth cells in various diseases within intestine and systemically.潘氏细胞在肠道和全身性多种疾病中的多方面作用。

本文引用的文献

1
Expression of α-Defensins, CD20+ B-lymphocytes, and Intraepithelial CD3+ T-lymphocytes in the Intestinal Mucosa of Patients with Liver Cirrhosis: Emerging Mediators of Intestinal Barrier Function.肝硬化患者肠黏膜中α-防御素、CD20+B 淋巴细胞和上皮内 CD3+T 淋巴细胞的表达：肠屏障功能的新介质。
Dig Dis Sci. 2018 Oct;63(10):2582-2592. doi: 10.1007/s10620-018-5146-9. Epub 2018 Jun 7.
2
Bacterial translocation in patients with liver cirrhosis: physiology, clinical consequences, and practical implications.肝硬化患者的细菌易位：生理学、临床后果及实际意义。
Expert Rev Gastroenterol Hepatol. 2018 Jul;12(7):641-656. doi: 10.1080/17474124.2018.1481747. Epub 2018 Jun 6.
3
Front Immunol. 2023 Mar 13;14:1115552. doi: 10.3389/fimmu.2023.1115552. eCollection 2023.
4
Cirrhosis-associated immune dysfunction.肝硬化相关免疫功能障碍。
Nat Rev Gastroenterol Hepatol. 2022 Feb;19(2):112-134. doi: 10.1038/s41575-021-00520-7. Epub 2021 Oct 26.
5
Multi-omic analysis in transgenic mice implicates omega-6/omega-3 fatty acid imbalance as a risk factor for chronic disease.多组学分析在转基因小鼠中表明，ω-6/ω-3 脂肪酸失衡是慢性病的一个风险因素。
Commun Biol. 2019 Jul 26;2:276. doi: 10.1038/s42003-019-0521-4. eCollection 2019.
Immune Dysfunction in Cirrhosis.
肝硬化中的免疫功能障碍
J Clin Transl Hepatol. 2017 Mar 28;5(1):50-58. doi: 10.14218/JCTH.2016.00056. Epub 2017 Mar 10.
4
A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia.宿主-微生物群相互作用介导了ω-6和ω-3脂肪酸对代谢性内毒素血症的相反作用。
Sci Rep. 2015 Jun 11;5:11276. doi: 10.1038/srep11276.
5
Pathological bacterial translocation in liver cirrhosis.肝硬化中的病理性细菌移位
J Hepatol. 2014 Jan;60(1):197-209. doi: 10.1016/j.jhep.2013.07.044. Epub 2013 Aug 28.
6
Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense.肝硬化大鼠肠道细菌易位与潘氏细胞抗菌宿主防御功能受损有关。
Hepatology. 2012 Apr;55(4):1154-63. doi: 10.1002/hep.24789. Epub 2012 Feb 15.
7
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin.表达人肠道防御素的转基因小鼠对肠道沙门氏菌病的保护作用。
Nature. 2003 Apr 3;422(6931):522-6. doi: 10.1038/nature01520. Epub 2003 Mar 19.
8
Gut-associated lymphoid T cell suppression enhances bacterial translocation in alcohol and burn injury.肠道相关淋巴组织T细胞抑制增强酒精和烧伤损伤中的细菌移位。
Am J Physiol Gastrointest Liver Physiol. 2002 Jun;282(6):G937-47. doi: 10.1152/ajpgi.00235.2001.
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Novel modified Ussing chamber for the study of absorption and secretion in human endoscopic biopsies.用于研究人类内镜活检组织吸收与分泌的新型改良尤斯灌流小室。
Acta Physiol Scand. 2001 Oct;173(2):213-22. doi: 10.1046/j.1365-201X.2001.00865.x.
10
Bacterial translocation of enteric organisms in patients with cirrhosis.肝硬化患者肠道细菌移位
J Hepatol. 2001 Jan;34(1):32-7. doi: 10.1016/s0168-8278(00)00013-1.