Pontzer N J, Hosko M J, Wilkison D M
Exp Neurol. 1986 Jan;91(1):127-35. doi: 10.1016/0014-4886(86)90030-0.
The action of tetrahydrocannabinol on the function of four multimodality responsive neocortical areas was assessed in the cat. Cats, anesthetized with alpha-chloralose, were subjected to auditory, somatosensory, and two types of visual stimulation. Simultaneous evoked field potentials and multiple-unit activity were recorded. The drug produced a significant reduction in evoked field responses at the three most rostral cortical areas, whereas responses at the posterior suprasylvian gyrus were spared. There were no significant differences between sensory modalities. In addition to being the first pharmacological study to demonstrate differential drug sensitivity between these polysensory areas, these studies localized an effect of tetrahydrocannabinol. Sensory evoked multiple-unit activity showed a pattern of change after THC consistent with a reduction in activity of pyramidal output cells and a concomitant increase in interneuron activity. The action of tetrahydrocannabinol on polysensory systems is important in attention and orientation.
在猫身上评估了四氢大麻酚对四个多模态反应性新皮质区域功能的作用。用α-氯醛糖麻醉的猫接受听觉、体感和两种视觉刺激。同时记录诱发场电位和多单位活动。该药物使最靠前的三个皮质区域的诱发场反应显著降低，而后上薛氏回的反应则未受影响。感觉模态之间没有显著差异。这些研究不仅是首次证明这些多感觉区域之间药物敏感性差异的药理学研究，还确定了四氢大麻酚的作用部位。感觉诱发的多单位活动在四氢大麻酚作用后呈现出一种变化模式，这与锥体细胞输出活动的减少以及中间神经元活动的相应增加一致。四氢大麻酚对多感觉系统的作用在注意力和定向方面很重要。
