• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种用于癌症基因治疗的通用肿瘤特异性启动子。

A Universal Tumor-Specific Promoter for Cancer Gene Therapy.

作者信息

Alekseenko I V, Pleshkan V V, Sass A V, Filyukova O B, Snezhkov E V, Sverdlov E D

机构信息

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.

Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia.

出版信息

Dokl Biochem Biophys. 2018 May;480(1):158-161. doi: 10.1134/S1607672918030092. Epub 2018 Jul 14.

DOI:10.1134/S1607672918030092
PMID:30008100
Abstract

An artificial double tandem tumor-specific promoter based on survivin and human telomerase reverse transcriptase gene promoters was constructed. Studies in in vitro and ex vivo therapeutic systems showed that the designed promoter exhibits a high activity in tumor cells, which is comparable to the activity of the CMV constitutive promoter.

摘要

构建了一种基于生存素和人端粒酶逆转录酶基因启动子的人工双串联肿瘤特异性启动子。体外和离体治疗系统研究表明，所设计的启动子在肿瘤细胞中表现出高活性，与巨细胞病毒组成型启动子的活性相当。

相似文献

1
A Universal Tumor-Specific Promoter for Cancer Gene Therapy.一种用于癌症基因治疗的通用肿瘤特异性启动子。
Dokl Biochem Biophys. 2018 May;480(1):158-161. doi: 10.1134/S1607672918030092. Epub 2018 Jul 14.
2
Suppression of hepatoma tumor growth by systemic administration of the phytotoxin gelonin driven by the survivin promoter.利用生存素启动子驱动植物毒素蓖麻蛋白系统给药抑制肝癌肿瘤生长。
Neoplasma. 2013;60(5):469-79. doi: 10.4149/neo_2013_061.
3
Oncolysis and suppression of tumor growth by a GFP-expressing oncolytic adenovirus controlled by an hTERT and CMV hybrid promoter.由人端粒酶逆转录酶（hTERT）和巨细胞病毒（CMV）杂交启动子控制的表达绿色荧光蛋白（GFP）的溶瘤腺病毒对肿瘤的溶解作用及肿瘤生长抑制作用
Cancer Gene Ther. 2006 Jul;13(7):720-3. doi: 10.1038/sj.cgt.7700944. Epub 2006 Feb 17.
4
Activity of the upstream component of tandem TERT/survivin promoters depends on features of the downstream component.串联 TERT/survivin 启动子上游元件的活性取决于下游元件的特征。
PLoS One. 2012;7(10):e46474. doi: 10.1371/journal.pone.0046474. Epub 2012 Oct 3.
5
A novel oncolytic adenovirus expressing Escherichia coli cytosine deaminase exhibits potent antitumor effect on human solid tumors.一种表达大肠杆菌胞嘧啶脱氨酶的新型溶瘤腺病毒对人实体瘤具有强大的抗肿瘤作用。
Cancer Biother Radiopharm. 2010 Aug;25(4):487-95. doi: 10.1089/cbr.2009.0752.
6
Tumor-specific gene expression using the survivin promoter is further increased by hypoxia.使用生存素启动子的肿瘤特异性基因表达会因缺氧而进一步增加。
Gene Ther. 2004 Aug;11(15):1215-23. doi: 10.1038/sj.gt.3302280.
7
Cancer targeted gene therapy of BikDD inhibits orthotopic lung cancer growth and improves long-term survival.BikDD的癌症靶向基因疗法可抑制原位肺癌生长并提高长期生存率。
Oncogene. 2009 Sep 17;28(37):3286-95. doi: 10.1038/onc.2009.187. Epub 2009 Jul 13.
8
Cancer-specific gene therapy.癌症特异性基因治疗。
Adv Genet. 2005;54:235-55. doi: 10.1016/S0065-2660(05)54010-0.
9
[Anti-tumor effect of suicide gene therapy using chimeric promoter plus radiotherapy on cancer cell lines].[嵌合启动子联合放射治疗的自杀基因疗法对癌细胞系的抗肿瘤作用]
Zhonghua Zhong Liu Za Zhi. 2011 Apr;33(4):245-50.
10
In vitro evaluation of cancer-specific NF-kappaB-CEA enhancer-promoter system for 5-fluorouracil prodrug gene therapy in colon cancer cell lines.用于结肠癌细胞系5-氟尿嘧啶前药基因治疗的癌症特异性核因子-κB-癌胚抗原增强子-启动子系统的体外评估
Br J Cancer. 2007 Sep 17;97(6):745-54. doi: 10.1038/sj.bjc.6603930. Epub 2007 Aug 7.

引用本文的文献

1
Targeted RASSF1A expression inhibits proliferation of HER2‑positive breast cancer cells .靶向RASSF1A表达可抑制HER2阳性乳腺癌细胞的增殖。
Exp Ther Med. 2023 Apr 11;25(6):245. doi: 10.3892/etm.2023.11944. eCollection 2023 Jun.
2
Targeted Overexpression of NDRG2 using Survivin Promoter Reduces Viability and Invasiveness of A549 Cell Line.使用生存素启动子靶向过表达NDRG2可降低A549细胞系的活力和侵袭性。
Avicenna J Med Biotechnol. 2023 Apr-Jun;15(2):84-90.
3
Plasmid DNA for Therapeutic Applications in Cancer.用于癌症治疗应用的质粒DNA。

本文引用的文献

1
Delivery of hypoxia and glioma dual-specific suicide gene using dexamethasone conjugated polyethylenimine for glioblastoma-specific gene therapy.使用地塞米松共轭聚乙烯亚胺递送缺氧和胶质瘤双特异性自杀基因用于胶质母细胞瘤特异性基因治疗。
Mol Pharm. 2014 Mar 3;11(3):938-50. doi: 10.1021/mp4006003. Epub 2014 Feb 3.
2
Activity of the upstream component of tandem TERT/survivin promoters depends on features of the downstream component.串联 TERT/survivin 启动子上游元件的活性取决于下游元件的特征。
PLoS One. 2012;7(10):e46474. doi: 10.1371/journal.pone.0046474. Epub 2012 Oct 3.
3
Bystander killing effect of tymidine kinase gene-transduced adult bone marrow stromal cells with ganciclovir on malignant glioma cells.
Pharmaceutics. 2022 Sep 3;14(9):1861. doi: 10.3390/pharmaceutics14091861.
4
Strategies for Targeting Gene Therapy in Cancer Cells With Tumor-Specific Promoters.利用肿瘤特异性启动子靶向癌细胞进行基因治疗的策略。
Front Oncol. 2020 Dec 14;10:605380. doi: 10.3389/fonc.2020.605380. eCollection 2020.
5
Searching for Promoters to Drive Stable and Long-Term Transgene Expression in Fibroblasts for Syngeneic Mouse Tumor Models.寻找启动子以驱动成纤维细胞中的稳定和长期转基因表达，用于同基因小鼠肿瘤模型。
Int J Mol Sci. 2020 Aug 24;21(17):6098. doi: 10.3390/ijms21176098.
用更昔洛韦处理的胸苷激酶基因转导的成人骨髓基质细胞对恶性胶质瘤细胞的旁观者杀伤作用
Neurol Med Chir (Tokyo). 2010;50(7):545-53. doi: 10.2176/nmc.50.545.
4
Use of GM-CSF as an adjuvant with cancer vaccines: beneficial or detrimental?GM-CSF 作为癌症疫苗佐剂的应用：有益还是有害？
Expert Rev Vaccines. 2010 May;9(5):519-25. doi: 10.1586/erv.10.40.
5
Hybrid promoters directed tBid gene expression to breast cancer cells by transcriptional targeting.通过转录靶向，杂交启动子将 tBid 基因表达导向乳腺癌细胞。
Biotechnol Prog. 2010 Mar-Apr;26(2):505-11. doi: 10.1002/btpr.353.
6
Effectiveness of HSV-tk suicide gene therapy driven by the Grp78 stress-inducible promoter in esophagogastric junction and gastric adenocarcinomas.由Grp78应激诱导启动子驱动的HSV-tk自杀基因疗法在食管胃交界腺癌和胃腺癌中的有效性。
J Gastrointest Surg. 2009 Jun;13(6):1044-51. doi: 10.1007/s11605-009-0839-1. Epub 2009 Mar 10.
7
A chimeric fusion of the hASH1 and EZH2 promoters mediates high and specific reporter and suicide gene expression and cytotoxicity in small cell lung cancer cells.hASH1和EZH2启动子的嵌合融合介导小细胞肺癌细胞中高特异性的报告基因和自杀基因表达及细胞毒性。
Cancer Gene Ther. 2008 Sep;15(9):563-75. doi: 10.1038/cgt.2008.24. Epub 2008 Apr 18.
8
Concordant expression of the telomerase-associated genes in non-small cell lung cancer.端粒酶相关基因在非小细胞肺癌中的一致性表达。
Eur J Surg Oncol. 2003 Sep;29(7):594-9. doi: 10.1016/s0748-7983(03)00108-2.
9
Clinical development of gene therapy for colorectal cancer.
Nat Rev Cancer. 2003 Aug;3(8):615-22. doi: 10.1038/nrc1147.
10
A novel combination of suicide gene therapy and histone deacetylase inhibitor for treatment of malignant melanoma.一种用于治疗恶性黑色素瘤的自杀基因疗法与组蛋白脱乙酰酶抑制剂的新型联合疗法。
Cancer Gene Ther. 2003 Mar;10(3):179-86. doi: 10.1038/sj.cgt.7700551.