Krutetskaya Z I, Milenina L S, Naumova A A, Butov S N, Antonov V G, Nozdrachev A D
St. Petersburg State University, St. Petersburg, 199034, Russia.
Dokl Biochem Biophys. 2018 May;480(1):162-165. doi: 10.1134/S1607672918030109. Epub 2018 Jul 14.
Using Fura-2AM microfluorimetry, we have shown for the first time that preincubation of macrophages with sigma-1 receptor antagonist haloperidol leads to a significant inhibition of the store-dependent Ca entry induced by endoplasmic Ca-ATPase inhibitors thapsigargin or cyclopiazonic acid in rat peritoneal macrophages. The results suggest the involvement of the sigma-1 receptor in the regulation of storedependent Ca entry in macrophages.
利用Fura-2AM显微荧光测定法，我们首次证明，用西格玛-1受体拮抗剂氟哌啶醇对巨噬细胞进行预孵育，会显著抑制内质网Ca-ATP酶抑制剂毒胡萝卜素或环匹阿尼酸在大鼠腹膜巨噬细胞中诱导的储存依赖性Ca内流。结果表明西格玛-1受体参与巨噬细胞中储存依赖性Ca内流的调节。
