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焦磷酸和乳清苷一磷酸对胞嘧啶脱氨酶调节特性的影响。

Effect of pyrophosphate and orotidine monophosphate on cytosine deaminase regulatory properties.

作者信息

West T P

出版信息

Experientia. 1985 Dec 15;41(12):1563-4. doi: 10.1007/BF01964808.

DOI:10.1007/BF01964808
PMID:3000814
Abstract

The maximal velocity of the reaction (Vmax) and the half-saturation constant (K0.5) values of the S. typhimurium cytosine deaminase were altered in the presence of its effectors, pyrophosphate and orotidine monophosphate. From the kinetics of orotidine monophosphate inhibition of cytosine deaminase, it was characterized as a mixed-type noncompetitive inhibitor.

摘要

在其效应物焦磷酸和乳清苷单磷酸存在的情况下,鼠伤寒沙门氏菌胞嘧啶脱氨酶的反应最大速度(Vmax)和半饱和常数(K0.5)值发生了改变。从乳清苷单磷酸对胞嘧啶脱氨酶的抑制动力学来看,它被表征为一种混合型非竞争性抑制剂。

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Effect of pyrophosphate and orotidine monophosphate on cytosine deaminase regulatory properties.焦磷酸和乳清苷一磷酸对胞嘧啶脱氨酶调节特性的影响。
Experientia. 1985 Dec 15;41(12):1563-4. doi: 10.1007/BF01964808.
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本文引用的文献

1
Procedure for the study of certain enzymes in minute amounts and its application to the investigation of cytosine deaminase.微量特定酶类的研究方法及其在胞嘧啶脱氨酶研究中的应用
J Biol Chem. 1948 Sep;175(2):993.
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Purification and properties of orotidylate decarboxylases from yeast and rat liver.酵母和大鼠肝脏中乳清酸脱羧酶的纯化及性质
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Repression of cytosine deaminase by pyrimidines in Salmonella typhimurium.鼠伤寒沙门氏菌中嘧啶对胞嘧啶脱氨酶的抑制作用。
J Bacteriol. 1982 Mar;149(3):1171-4. doi: 10.1128/jb.149.3.1171-1174.1982.
4
Purification and some properties of cytosine deaminase from Salmonella typhimurium.鼠伤寒沙门氏菌胞嘧啶脱氨酶的纯化及某些性质
Biochim Biophys Acta. 1982 Nov 24;719(2):251-8. doi: 10.1016/0304-4165(82)90096-4.
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
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Baker's yeast cytosine deaminase. Some enzymic properties and allosteric inhibition by nucleosides and nucleotides.贝克酵母胞嘧啶脱氨酶。一些酶学性质以及核苷和核苷酸的变构抑制作用。
Biochemistry. 1971 Nov;10(23):4270-6. doi: 10.1021/bi00799a018.
7
Repression of enzyme synthesis of the pyrimidine pathway in Salmonella typhimurium.鼠伤寒沙门氏菌中嘧啶途径酶合成的抑制作用
J Bacteriol. 1973 Sep;115(3):1071-6. doi: 10.1128/jb.115.3.1071-1076.1973.
8
Physiological factors in the regulation of alkaline phosphatase synthesis in Escherichia coli.大肠杆菌中碱性磷酸酶合成调控的生理因素
J Bacteriol. 1972 May;110(2):616-23. doi: 10.1128/jb.110.2.616-623.1972.
9
Biosynthesis of bacterial glycogen IX: regulatory properties of the adenosine diphosphate glucose pyrophosphrylases of the Enterobacterieae.细菌糖原IX的生物合成:肠杆菌科二磷酸腺苷葡萄糖焦磷酸化酶的调节特性
Arch Biochem Biophys. 1971 Feb;142(2):675-92. doi: 10.1016/0003-9861(71)90534-0.
10
Salmonella typhimurium mutants defective in cytidine monophosphate kinase (cmk).鼠伤寒沙门氏菌胞苷单磷酸激酶(cmk)缺陷型突变体。
J Bacteriol. 1974 Dec;120(3):1370-9. doi: 10.1128/jb.120.3.1370-1379.1974.