Bragintseva L M, Andreeva L A, Andreev A A, Ustyniuk T K
Farmakol Toksikol. 1985 Sep-Oct;48(5):39-42.
A study was made of the effect of PGE2, ethyl ether and a carbohydrate derivative of PGE2 on the sensitivity to acetylcholine (ACh) of identified neurons of the mollusk pond snail. The response recorded in the mode of membrane potential fixation diminished in the presence of PGE2 and its derivatives. The rate of the decrease and the degree of the response blockade depended on the substance concentration. Washing of PGE2 made the neuronal sensitivity to ACh return to normal. With the use of PGE2 derivatives the sensitivity recovery was incomplete. The radioimmunochemical technique has demonstrated PGE2 to raise the cAMP level in the pond snail brain.
研究了前列腺素E2（PGE2）、乙醚和PGE2的一种碳水化合物衍生物对软体动物池塘蜗牛特定神经元对乙酰胆碱（ACh）敏感性的影响。在膜电位固定模式下记录的反应在PGE2及其衍生物存在时减弱。下降速率和反应阻断程度取决于物质浓度。冲洗PGE2可使神经元对ACh的敏感性恢复正常。使用PGE2衍生物时，敏感性恢复不完全。放射免疫化学技术已证明PGE2可提高池塘蜗牛脑中的环磷酸腺苷（cAMP）水平。
