Filippov A K, Porotikov V I
Biofizika. 1983 Sep-Oct;28(5):821-5.
It has been shown on the trabecules of frog auricle by potential recording, that prostaglandin E1 (PGE1) increases the number of working calcium channels of the membrane. PGE1, PGE2, acetylcholine, indometacin--inhibitor of PG synthesis and aminazine 2--calmodulin inhibitor do not decrease novodrin--induced intensification of calcium current. The results suggest that a change of cAMP level inside the cell modulates the number of working calcium channels. PG and calmodulin are not necessary for novodrin--stimulation of adenylatcyclase (AC). The effect of acetylcholine is not connected with AC inhibition.
通过电位记录已表明，在蛙心耳小梁上，前列腺素E1（PGE1）可增加膜上工作钙通道的数量。PGE1、PGE2、乙酰胆碱、PG合成抑制剂吲哚美辛以及钙调蛋白抑制剂氯丙嗪均不会降低新福林诱导的钙电流增强。结果表明，细胞内cAMP水平的变化调节工作钙通道的数量。PG和钙调蛋白对于新福林刺激腺苷酸环化酶（AC）并非必需。乙酰胆碱的作用与AC抑制无关。
