Feldman R D
Fed Proc. 1986 Jan;45(1):48-50.
Aging decreases hormone responsiveness in several receptor systems. In this article I consider both physiological and biochemical studies supporting the hypothesis that beta-adrenergic receptor responsiveness is reduced with aging in humans. Reduced chronotropic and vasodilator responses to the beta-receptor agonists isoproterenol and metaproterenol have been demonstrated. In human leukocytes a reduction in adenylate cyclase (EC 4.6.1.1) activity occurs with aging. More recently it has been suggested that this reduction in beta-adrenergic responsiveness with aging may be caused by an uncoupling of the beta receptor from the catalytic component.
衰老会降低多个受体系统中的激素反应性。在本文中，我将探讨支持人类β-肾上腺素能受体反应性随衰老而降低这一假说的生理学和生物化学研究。对β受体激动剂异丙肾上腺素和间羟异丙肾上腺素的变时性和血管舒张反应降低已得到证实。在人类白细胞中，腺苷酸环化酶（EC 4.6.1.1）活性会随着衰老而降低。最近有人提出，衰老导致的β-肾上腺素能反应性降低可能是由于β受体与催化成分解偶联所致。
