Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, China; Shantou University Medical College, Shantou 515041, China.
Shantou University Medical College, Shantou 515041, China; Department of anesthesiology, Shenzhen Second People's Hospital, Shenzhen 518039, China.
Clin Chim Acta. 2018 Oct;485:262-271. doi: 10.1016/j.cca.2018.07.003. Epub 2018 Jul 7.
Colorectal neoplasia differentially expressed (CRNDE), a 1910-nt lncRNA encoded on human chromosome 16, has been found to be involved in various cancers. Nevertheless, the clinical and diagnostic values of CRNDE in tumors still need to be explored. In this review, we aimed to elucidate the clinical role of CRNDE in cancer by searching all correlative literature, and we sequentially explored the association between CRNDE levels and overall survival (OS) or clinicopathological characteristics of cancer.
We conducted a database search of PubMed, Wanfang Data, Ovid, SinoMed, China National Knowledge Infrastructure, Cochrane Library, and Web of Science (up to January 1, 2018). The pooled odds ratio (OR) and hazard ratio (HR) were used to assess extents of correlation between CRNDE and cancer prognosis. After identification of the inclusion and exclusion criteria, 12 articles including 1361 patients were selected for this review.
The results suggested that high levels of CRNDE were highly related to poor OS in tumor patients, with pooled HRs of 2.314 (1.894-2.826, P < .001, fixed-effects model). Likewise, we also found that high CRNDE expression was correlated with high tumor stage [OR: 3.340, 95% confidence interval (CI): 2.417-4.616, P < .001, random-effects model] and lymph node metastasis (OR: 3.027, 95% CI: 2.071-4.425, P = .004, random-effects model).
Our findings demonstrated that CRNDE may modify susceptibility for various cancers and may serve as a new predictive factor for prognosis and diagnosis in different types of cancers.
差异表达的结直肠肿瘤相关基因（CRNDE）是一种位于人类染色体 16 上的 1910nt 的长链非编码 RNA，已被发现参与多种癌症。然而，CRNDE 在肿瘤中的临床和诊断价值仍有待探索。在本综述中，我们通过检索所有相关文献，旨在阐明 CRNDE 在癌症中的临床作用，并进一步探讨 CRNDE 水平与癌症患者总生存（OS）或临床病理特征之间的相关性。
我们对 PubMed、万方数据、Ovid、中国生物医学文献数据库、中国知网、Cochrane 图书馆和 Web of Science 数据库进行了数据库检索（截至 2018 年 1 月 1 日）。采用合并比值比（OR）和风险比（HR）评估 CRNDE 与癌症预后的相关性。在确定纳入和排除标准后，选择了 12 篇包含 1361 名患者的文章进行综述。
结果表明，肿瘤患者中 CRNDE 高表达与 OS 不良显著相关，合并 HR 为 2.314（1.894-2.826，P<0.001，固定效应模型）。同样，我们还发现 CRNDE 高表达与肿瘤分期较高[OR：3.340，95%置信区间（CI）：2.417-4.616，P<0.001，随机效应模型]和淋巴结转移（OR：3.027，95% CI：2.071-4.425，P=0.004，随机效应模型）相关。
我们的研究结果表明，CRNDE 可能改变多种癌症的易感性，并可能作为不同类型癌症预后和诊断的新预测因子。
