长非编码 RNA CRNDE 作为实体瘤潜在的预后生物标志物：一项荟萃分析。
Long non-coding RNA CRNDE as a potential prognostic biomarker in solid tumors: A meta-analysis.
机构信息
Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Department of Tumor Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
出版信息
Clin Chim Acta. 2018 Jun;481:99-107. doi: 10.1016/j.cca.2018.02.039. Epub 2018 Mar 1.
BACKGROUND AND AIM
Long non-coding RNA colorectal neoplasia differentially expressed (CRNDE) has been demonstrated to be highly expressed in many malignant tumors; however, the role of CRNDE in cancer remains undetermined because of limitations in sample size. We conducted a meta-analysis to assess the role of CRNDE in cancer.
METHODS
PubMed, Medline, Cochrane Library, Web of Science, EMBASE database, Ovid, Chinese CNKI, and Chinese WanFang database were systematically searched. The relation between CRNDE and the clinicopathological characteristics and prognosis of patients with cancer was determined using pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence interval (CI).
RESULTS
Thirteen studies with 1570 patients were included. The pooled results indicated that high CRNDE expression was related to lymph node metastasis (YES vs. NO: OR = 3.50, 95% CI = [1.05, 8.09]) and TNM stage (I + II vs. III + IV: OR = 0.26, 95% CI = [0.18, 0.37]) but not to gender, tumor size, and differentiation. High CRNDE expression indicated poor overall survival (OS) (HR = 2.06, 95% CI = [1.66, 2.47]). CRNDE could be an independent predictive factor for OS (HR = 1.62, 95% CI = [1.15, 2.08]) in patients with cancer.
CONCLUSION
Therefore, high CRNDE expression was associated with advanced clinicopathological characteristics, and CRNDE could be used as a reliable prognostic biomarker in human cancer. However, more high-quality studies with a large sample size are needed to support this meta-analysis.
背景与目的
长链非编码 RNA 结直肠肿瘤差异表达（CRNDE）在许多恶性肿瘤中表达水平较高；然而，由于样本量有限，CRNDE 在癌症中的作用仍不确定。我们进行了一项荟萃分析，以评估 CRNDE 在癌症中的作用。
方法
系统检索了 PubMed、Medline、Cochrane 图书馆、Web of Science、EMBASE 数据库、Ovid、中国知网（CNKI）和中国万方数据库。使用合并的优势比（OR）和风险比（HR）及其 95%置信区间（CI），确定 CRNDE 与癌症患者的临床病理特征和预后之间的关系。
结果
纳入了 13 项包含 1570 例患者的研究。汇总结果表明，高 CRNDE 表达与淋巴结转移（是 vs. 否：OR=3.50，95%CI=[1.05, 8.09]）和 TNM 分期（I+II 期 vs. III+IV 期：OR=0.26，95%CI=[0.18, 0.37]）有关，但与性别、肿瘤大小和分化无关。高 CRNDE 表达提示总体生存（OS）不良（HR=2.06，95%CI=[1.66, 2.47]）。CRNDE 可作为癌症患者 OS 的独立预测因子（HR=1.62，95%CI=[1.15, 2.08]）。
结论
因此，高 CRNDE 表达与较先进的临床病理特征相关，CRNDE 可作为人类癌症的可靠预后生物标志物。然而，需要更多高质量、大样本量的研究来支持本荟萃分析。
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