Department of Cardiology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Int J Med Sci. 2018 May 22;15(8):808-815. doi: 10.7150/ijms.25140. eCollection 2018.
genes, , encode cardiac transcription factors, Irx1-6 in most mammals. These six transcription factors are expressed in different patterns mainly in the ventricular part of the heart. Existing researches show that genes play key roles in the differentiation and development of ventricular conduction system and the establishment and maintenance of gradient expression of potassium channels, Kv4.2. Our main focus of this review is on the recent advances in the discovery of above-mentioned genes and the function of the encoding products, how genes establish ventricular conduction system and regulate ventricular repolarization, how the individual and complementary functions can be verified to complement our cognition and leads to novel therapeutic approaches.
基因，编码心脏转录因子，Irx1-6 在大多数哺乳动物中。这六个转录因子的表达模式不同，主要在心脏的心室部分。现有研究表明，这些基因在心室传导系统的分化和发育以及钾通道 Kv4.2 梯度表达的建立和维持中起关键作用。我们的综述重点是上述基因的发现和编码产物的功能的最新进展，基因如何建立心室传导系统并调节心室复极化，个体和互补功能如何被验证以补充我们的认知，并导致新的治疗方法。
