Hunter Jervaughn D, Mesfin Joshua M, Ahmed Tanzeel, Chen Alexander, Reimold Kate, Hancko Arielle, Braden Rebecca L, Davis Michael E, Christman Karen L
Shu Chien-Gene Lay Department of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California-San Diego, San Diego, California, USA.
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.
JACC Basic Transl Sci. 2024 Mar 6;9(3):322-338. doi: 10.1016/j.jacbts.2024.01.006. eCollection 2024 Mar.
This study evaluates the effectiveness of myocardial matrix (MM) hydrogels in mitigating negative right ventricular (RV) remodeling in a rat model of RV heart failure. The goal was to assess whether a hydrogel derived from either the right or left ventricle could promote cardiac repair. Injured rat right ventricles were injected with either RV-or left ventricular-derived MM hydrogels. Both hydrogels improved RV function and morphology and reduced negative remodeling. This study supports the potential of injectable biomaterial therapies for treating RV heart failure.
本研究评估了心肌基质（MM）水凝胶在减轻右心室（RV）心力衰竭大鼠模型中右心室负性重构方面的有效性。目的是评估源自右心室或左心室的水凝胶是否能够促进心脏修复。将源自右心室或左心室的MM水凝胶注射到受伤的大鼠右心室中。两种水凝胶均改善了右心室功能和形态，并减少了负性重构。本研究支持了可注射生物材料疗法治疗右心室心力衰竭的潜力。
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