心肌基质水凝胶减轻右心衰竭模型中的负性重塑并改善功能。

Myocardial Matrix Hydrogels Mitigate Negative Remodeling and Improve Function in Right Heart Failure Model.

作者信息

Hunter Jervaughn D, Mesfin Joshua M, Ahmed Tanzeel, Chen Alexander, Reimold Kate, Hancko Arielle, Braden Rebecca L, Davis Michael E, Christman Karen L

机构信息

Shu Chien-Gene Lay Department of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California-San Diego, San Diego, California, USA.

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.

出版信息

JACC Basic Transl Sci. 2024 Mar 6;9(3):322-338. doi: 10.1016/j.jacbts.2024.01.006. eCollection 2024 Mar.

DOI:10.1016/j.jacbts.2024.01.006

PMID:38559631

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10978413/

Abstract

This study evaluates the effectiveness of myocardial matrix (MM) hydrogels in mitigating negative right ventricular (RV) remodeling in a rat model of RV heart failure. The goal was to assess whether a hydrogel derived from either the right or left ventricle could promote cardiac repair. Injured rat right ventricles were injected with either RV-or left ventricular-derived MM hydrogels. Both hydrogels improved RV function and morphology and reduced negative remodeling. This study supports the potential of injectable biomaterial therapies for treating RV heart failure.

摘要

本研究评估了心肌基质（MM）水凝胶在减轻右心室（RV）心力衰竭大鼠模型中右心室负性重构方面的有效性。目的是评估源自右心室或左心室的水凝胶是否能够促进心脏修复。将源自右心室或左心室的MM水凝胶注射到受伤的大鼠右心室中。两种水凝胶均改善了右心室功能和形态，并减少了负性重构。本研究支持了可注射生物材料疗法治疗右心室心力衰竭的潜力。