Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
Int J Med Sci. 2018 Jun 12;15(9):921-928. doi: 10.7150/ijms.26076. eCollection 2018.
Drug addiction is reported to have adverse effects in male reproduction. Dextromethorphan (DXM) administration was used in this study as a model of addiction in rats, and various treatments including the use of pre-germinated brown rice (PGBR) were investigated for their effects on the changes of sperm quality, testicular structure and androgen receptor (AR) expressions in rats receiving DXM. The results demonstrated that these animals showed significant reduction in all parameters of sperm quality, an increase in abnormal testicular structure and decreased androgen receptor expression in spermatogenic, Sertoli and Leydig cells. However, different effects of the treatments applied in this study were observed with the greatest recovery effect from treatment with PGBR. Sperm motility and sperm concentration reverted to normal after treatment with PGBR for 60 days. Moreover, all parameters of testicular structure also returned to normal after 60 days of PGBR treatment, as well as AR expression in Sertoli and Leydig cells. Therefore, we have demonstrated that PGBR treatment can reverse the changes in sperm quality, testicular structure and AR expression in addicted animals and PGBR may be a novel therapeutic strategy for the treatment of drug addiction.
据报道，药物成瘾对男性生殖有不良影响。本研究采用右美沙芬（DXM）给药作为大鼠成瘾模型，探讨了各种治疗方法（包括使用预发芽糙米（PGBR））对接受 DXM 大鼠精子质量变化、睾丸结构和雄激素受体（AR）表达的影响。结果表明，这些动物的精子质量各项参数显著降低，睾丸结构异常增加，生精细胞、支持细胞和间质细胞中的雄激素受体表达减少。然而，本研究中应用的不同治疗方法有不同的效果，其中 PGBR 的治疗效果最佳。用 PGBR 治疗 60 天后，精子活力和精子浓度恢复正常。此外，60 天 PGBR 治疗后睾丸结构的所有参数也恢复正常，以及支持细胞和间质细胞中的 AR 表达。因此，我们已经证明，PGBR 治疗可以逆转成瘾动物的精子质量、睾丸结构和 AR 表达的变化，PGBR 可能是治疗药物成瘾的一种新的治疗策略。
