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（L.）Webb ex Prantl水提取物对慢性心力衰竭大鼠心室重构的影响

Effect of Aqueous Extract from (L.) Webb ex Prantl on Ventricular Remodeling in Chronic Heart Failure Rats.

作者信息

Luo Ying, Sun Zhiqiang, Hu Pengfei, Wu Yuanhong, Yu Weiwei, Huang Shuwei

机构信息

The Second Clinical Medicine College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310005, China.

出版信息

Evid Based Complement Alternat Med. 2018 Jun 13;2018:1904081. doi: 10.1155/2018/1904081. eCollection 2018.

DOI:10.1155/2018/1904081
PMID:30008784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6020489/
Abstract

OBJECTIVE

(L.) Webb ex Prantl (DS) is a traditional Chinese medicine. Our current study was to evaluate the effect of DS on ventricular remodeling in chronic heart failure (HF) rats and its underlying mechanism.

METHODS

The rat chronic heart failure model induced by suprarenal abdominal aortic coarctation surgery. The survival rats were randomly divided into 3 groups: the sham group (n=6), the HF group (n=6), and the HF+DS group (n=6). After 3 months of drug intervention, we examined the effects of DS by Sirius Red staining, electron microscopy, echocardiography, hemodynamic measurement, and TUNEL and explored the underlying mechanism by Western blotting.

RESULTS

We found that rats treated with DS showed improved cardiac function and less tissue damage compared to untreated group. Additionally, DS could reduce the cardiomyocytes apoptosis, decrease the ratio of Bax/bcl-2 and Caspase-3 expression, and enhance the phosphorylation of Akt protein expression.

CONCLUSION

Our study suggested that rats treated with DS after suprarenal abdominal aortic coarctation surgery showed attenuated cardiac fibrosis and apoptosis, and the protective effect may be correlated with the activation of PI3k/Akt/mTOR dependent manner.

摘要

目的

（L.）Webb ex Prantl（丹参）是一种传统中药。我们当前的研究旨在评估丹参对慢性心力衰竭（HF）大鼠心室重构的影响及其潜在机制。

方法

采用腹主动脉缩窄术建立大鼠慢性心力衰竭模型。存活的大鼠随机分为3组：假手术组（n = 6）、HF组（n = 6）和HF + 丹参组（n = 6）。药物干预3个月后，通过天狼星红染色、电子显微镜、超声心动图、血流动力学测量和TUNEL检测丹参的作用，并通过蛋白质印迹法探索其潜在机制。

结果

我们发现，与未治疗组相比，丹参治疗的大鼠心脏功能改善，组织损伤减轻。此外，丹参可减少心肌细胞凋亡，降低Bax/bcl - 2比值和Caspase - 3表达，并增强Akt蛋白表达的磷酸化。

结论

我们的研究表明，腹主动脉缩窄术后用丹参治疗的大鼠心脏纤维化和凋亡减轻，其保护作用可能与PI3k/Akt/mTOR依赖性方式的激活有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f81/6020489/aee85f42e0f9/ECAM2018-1904081.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f81/6020489/8402a2a3faa6/ECAM2018-1904081.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f81/6020489/3e6f6295ea82/ECAM2018-1904081.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f81/6020489/f0ec1cfb1004/ECAM2018-1904081.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f81/6020489/82746a4c18f3/ECAM2018-1904081.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f81/6020489/aee85f42e0f9/ECAM2018-1904081.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f81/6020489/8402a2a3faa6/ECAM2018-1904081.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f81/6020489/3e6f6295ea82/ECAM2018-1904081.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f81/6020489/f0ec1cfb1004/ECAM2018-1904081.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f81/6020489/82746a4c18f3/ECAM2018-1904081.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f81/6020489/aee85f42e0f9/ECAM2018-1904081.005.jpg

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