Xu Heng, Yuan Zhen-Zhen, Ma Xiao, Wang Chi, Suo You-Rui, Wang Hong-Lun, Wang Xiao-Yan, Bai Bo
a Key Laboratory of Tibetan Medicine Research , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xining 810008 , China.
d University of Chinese Academy of Sciences , Beijing 100039 , China.
J Asian Nat Prod Res. 2018 Mar;20(3):292-298. doi: 10.1080/10286020.2017.1321636. Epub 2017 May 2.
A new triterpenoid, namely myricarin C (compound 1), together with three known compounds myricarin A (compound 2) and myricarin B (compound 3), 3α-hydroxy-D-friedoolean-14-en-28-oic acid (compound 4), was isolated from the overground part of Myricaria squamosa. Compound 2 and compound 3 existed in the solution by the form of cis-trans isomers. Their structures were elucidated by means of extensive spectroscopic methods, including 1D-NMR, 2D-NMR, and HR-ESI-MS. The antioxidant properties of all compounds were calculated based on the DPPH radical scavenging activities. Results showed that myricarin A and myricarin C had general antioxidant activities with EC values of 40.90 μg/ml, 42.22 μg/ml, respectively, compared to the control, rutin (5.17 μg/ml). The EC values of myricarin B was 195.81 μg/ml. Compound 4 had no antioxidant activities.
从水柏枝的地上部分分离得到一种新的三萜类化合物，即杨梅素C（化合物1），以及三种已知化合物杨梅素A（化合物2）、杨梅素B（化合物3）、3α-羟基-D-去甲齐墩果-14-烯-28-酸（化合物4）。化合物2和化合物3以顺反异构体的形式存在于溶液中。通过广泛的光谱方法，包括一维核磁共振、二维核磁共振和高分辨电喷雾电离质谱对它们的结构进行了鉴定。基于二苯基苦味酰基自由基清除活性计算了所有化合物的抗氧化性能。结果表明，与对照芦丁（5.17μg/ml）相比，杨梅素A和杨梅素C具有一般的抗氧化活性，其半数有效浓度（EC）值分别为40.90μg/ml、42.22μg/ml。杨梅素B的EC值为195.81μg/ml。化合物4没有抗氧化活性。
