• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微小RNA-205在肝细胞癌中表达下调，并通过直接靶向血管内皮生长因子A抑制细胞生长和转移。

MicroRNA-205 is downregulated in hepatocellular carcinoma and inhibits cell growth and metastasis via directly targeting vascular endothelial growth factor A.

作者信息

Zhao Xuya, Zhou Shi, Wang Dazhi, He Wei, Li Junxiang, Zhang Shuai

机构信息

Department of Interventional Radiology, Guizhou Cancer Hospital, Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou 550003, P.R. China.

出版信息

Oncol Lett. 2018 Aug;16(2):2207-2214. doi: 10.3892/ol.2018.8933. Epub 2018 Jun 8.

DOI:10.3892/ol.2018.8933
PMID:30008920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6036469/
Abstract

MicroRNAs (miRs) are an emerging class of non-coding, endogenous and small RNA molecules that serve important functions in tumorigenesis and development. The present study investigated the expression, functions and molecular mechanism underlying miR-205 in hepatocellular carcinoma. miR-205 was downregulated in hepatocellular carcinoma tissues and cell lines. Ectopic miR-205 expression suppressed hepatocellular carcinoma cell proliferation, migration and invasion . In addition, vascular endothelial growth factor A (VEGFA) was identified as a functional downstream target of miR-205 in hepatocellular carcinoma. Furthermore, knockdown of VEGFA revealed the same functions with miR-205 overexpression in hepatocellular carcinoma cells. These results provided evidence that miR-205 served important functions in the inhibition of hepatocellular carcinoma cells growth and metastasis via directly targeting VEGFA, which indicated that miR-205 may have therapeutic value for hepatocellular carcinoma.

摘要

微小RNA（miRs）是一类新出现的非编码、内源性小RNA分子，在肿瘤发生和发展过程中发挥着重要作用。本研究探讨了miR-205在肝细胞癌中的表达、功能及分子机制。miR-205在肝细胞癌组织和细胞系中表达下调。异位表达miR-205可抑制肝癌细胞的增殖、迁移和侵袭。此外，血管内皮生长因子A（VEGFA）被确定为miR-205在肝细胞癌中的功能性下游靶点。此外，敲低VEGFA在肝癌细胞中显示出与过表达miR-205相同的功能。这些结果证明，miR-205通过直接靶向VEGFA在抑制肝癌细胞生长和转移中发挥重要作用，这表明miR-205可能对肝细胞癌具有治疗价值。

相似文献

1
MicroRNA-205 is downregulated in hepatocellular carcinoma and inhibits cell growth and metastasis via directly targeting vascular endothelial growth factor A.微小RNA-205在肝细胞癌中表达下调，并通过直接靶向血管内皮生长因子A抑制细胞生长和转移。
Oncol Lett. 2018 Aug;16(2):2207-2214. doi: 10.3892/ol.2018.8933. Epub 2018 Jun 8.
2
MicroRNA-101 suppresses migration and invasion via targeting vascular endothelial growth factor-C in hepatocellular carcinoma cells.微小RNA-101通过靶向血管内皮生长因子-C抑制肝癌细胞的迁移和侵袭。
Oncol Lett. 2016 Jan;11(1):433-438. doi: 10.3892/ol.2015.3832. Epub 2015 Oct 27.
3
miR-144 inhibits growth and metastasis of cervical cancer cells by targeting VEGFA and VEGFC.微小RNA-144通过靶向血管内皮生长因子A和血管内皮生长因子C抑制宫颈癌细胞的生长和转移。
Exp Ther Med. 2018 Jan;15(1):562-568. doi: 10.3892/etm.2017.5392. Epub 2017 Oct 30.
4
MicroRNA-204 suppressed proliferation and motility capacity of human hepatocellular carcinoma via directly targeting zinc finger E-box binding homeobox 2.微小RNA-204通过直接靶向锌指E盒结合同源框蛋白2抑制人肝癌细胞的增殖和运动能力。
Oncol Lett. 2017 May;13(5):3823-3830. doi: 10.3892/ol.2017.5907. Epub 2017 Mar 24.
5
MicroRNA‑302a inhibits cell proliferation and invasion, and induces cell apoptosis in hepatocellular carcinoma by directly targeting VEGFA.微小 RNA-302a 通过直接靶向 VEGFA 抑制肝癌细胞增殖、侵袭，诱导细胞凋亡。
Mol Med Rep. 2017 Nov;16(5):6360-6367. doi: 10.3892/mmr.2017.7312. Epub 2017 Aug 22.
6
MicroRNA-125b suppresses the migration and invasion of hepatocellular carcinoma cells by targeting transcriptional coactivator with PDZ-binding motif.微小RNA-125b通过靶向含PDZ结合基序的转录共激活因子来抑制肝癌细胞的迁移和侵袭。
Oncol Lett. 2015 Apr;9(4):1971-1975. doi: 10.3892/ol.2015.2973. Epub 2015 Feb 17.
7
MicroRNA-340 inhibits the proliferation and invasion of hepatocellular carcinoma cells by targeting JAK1.微小RNA-340通过靶向JAK1抑制肝癌细胞的增殖和侵袭。
Biochem Biophys Res Commun. 2017 Jan 29;483(1):578-584. doi: 10.1016/j.bbrc.2016.12.102. Epub 2016 Dec 18.
8
MiR-195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA.微小RNA-195通过靶向成纤维细胞生长因子2（FGF2）和血管内皮生长因子A（VEGFA），成为肝细胞癌转移的关键负调控因子。
Int J Clin Exp Pathol. 2015 Nov 1;8(11):14110-20. eCollection 2015.
9
Knockdown of TUG1 by shRNA inhibited renal cell carcinoma formation by miR-299-3p/VEGF axis in vitro and in vivo.短发夹 RNA 敲低 TUG1 通过 miR-299-3p/VEGF 轴抑制体外和体内肾细胞癌的形成。
Eur J Pharmacol. 2019 Oct 5;860:172536. doi: 10.1016/j.ejphar.2019.172536. Epub 2019 Jul 13.
10
MicroRNA-299-3p suppresses proliferation and invasion by targeting VEGFA in human colon carcinoma.微小 RNA-299-3p 通过靶向血管内皮生长因子 A 抑制人结肠癌细胞的增殖和侵袭。
Biomed Pharmacother. 2017 Sep;93:1047-1054. doi: 10.1016/j.biopha.2017.07.030. Epub 2017 Jul 18.

引用本文的文献

1
Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives.健康与疾病中的血管内皮生长因子信号传导：从分子机制到治疗前景
Signal Transduct Target Ther. 2025 May 19;10(1):170. doi: 10.1038/s41392-025-02249-0.
2
miR-205-5p Modulates High Glucose-Induced VEGFA Levels in Diabetic Mice and ARPE-19 Cells.miR-205-5p调节糖尿病小鼠和ARPE-19细胞中高糖诱导的VEGFA水平。
Antioxidants (Basel). 2025 Feb 14;14(2):218. doi: 10.3390/antiox14020218.
3
regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway.通过HIF-1α/VEGF途径调节肝细胞癌中的血管生成和肿瘤进展。
Biomol Biomed. 2024 Dec 11;25(1):189-209. doi: 10.17305/bb.2024.10794.
4
Potential Common Molecular Mechanisms Between Periodontitis and Hepatocellular Carcinoma: A Bioinformatic Analysis and Validation.牙周炎和肝细胞癌之间的潜在共同分子机制：生物信息学分析与验证。
Cancer Genomics Proteomics. 2023 Nov-Dec;20(6):602-616. doi: 10.21873/cgp.20409.
5
Non-coding RNAs: Role in diabetic foot and wound healing.非编码RNA：在糖尿病足与伤口愈合中的作用
World J Diabetes. 2022 Dec 15;13(12):1001-1013. doi: 10.4239/wjd.v13.i12.1001.
6
Micronome Revealed miR-205-5p as Key Regulator of VEGFA During Cancer Related Angiogenesis in Hepatocellular Carcinoma.微核揭示 miR-205-5p 作为肝癌相关血管生成过程中 VEGFA 的关键调控因子。
Mol Biotechnol. 2023 Jul;65(7):1178-1186. doi: 10.1007/s12033-022-00619-5. Epub 2022 Dec 3.
7
microRNA-205 in prostate cancer: Overview to clinical translation.微小 RNA-205 在前列腺癌中的作用：从临床前研究到临床转化。
Biochim Biophys Acta Rev Cancer. 2022 Nov;1877(6):188809. doi: 10.1016/j.bbcan.2022.188809. Epub 2022 Oct 1.
8
Bioinformatics-based analysis of SUMOylation-related genes in hepatocellular carcinoma reveals a role of upregulated SAE1 in promoting cell proliferation.基于生物信息学的肝细胞癌中类泛素化相关基因分析揭示了上调的SAE1在促进细胞增殖中的作用。
Open Med (Wars). 2022 Jul 6;17(1):1183-1202. doi: 10.1515/med-2022-0510. eCollection 2022.
9
MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression.来源于糖尿病足溃疡伤口液的细胞外囊泡中的 miR-195-5p 和 miR-205-5p 通过抑制 VEGFA 表达来减少血管生成。
Aging (Albany NY). 2021 Aug 9;13(15):19805-19821. doi: 10.18632/aging.203393.
10
Enhanced expression of miR-889 forecasts an unfavorable prognosis and facilitates cell progression in hepatocellular carcinoma.miR-889的表达增强预示着肝细胞癌预后不良并促进细胞进展。
Diagn Pathol. 2021 Jun 11;16(1):51. doi: 10.1186/s13000-021-01111-5.

本文引用的文献

1
miR-205 promotes proliferation and invasion of laryngeal squamous cell carcinoma by suppressing CDK2AP1 expression.微小RNA-205通过抑制细胞周期蛋白依赖性激酶2相关蛋白1的表达促进喉鳞状细胞癌的增殖和侵袭。
Biol Res. 2015 Oct 29;48:60. doi: 10.1186/s40659-015-0052-5.
2
miR-205 promotes epithelial-mesenchymal transition by targeting AKT signaling in endometrial cancer cells.微小RNA-205通过靶向子宫内膜癌细胞中的AKT信号传导促进上皮-间质转化。
J Obstet Gynaecol Res. 2015 Oct;41(10):1653-60. doi: 10.1111/jog.12756.
3
miR-205 suppresses the proliferative and migratory capacity of human osteosarcoma Mg-63 cells by targeting VEGFA.微小RNA-205通过靶向血管内皮生长因子A抑制人骨肉瘤Mg-63细胞的增殖和迁移能力。
Onco Targets Ther. 2015 Sep 16;8:2635-42. doi: 10.2147/OTT.S80088. eCollection 2015.
4
Modulatory role of miR-205 in angiogenesis and progression of thyroid cancer.miR-205在甲状腺癌血管生成和进展中的调节作用。
J Mol Endocrinol. 2015 Dec;55(3):183-96. doi: 10.1530/JME-15-0182. Epub 2015 Sep 4.
5
MiR-205 promotes motility of ovarian cancer cells via targeting ZEB1.微小RNA-205通过靶向锌指E盒结合蛋白1促进卵巢癌细胞的运动性。
Gene. 2015 Dec 15;574(2):330-6. doi: 10.1016/j.gene.2015.08.017. Epub 2015 Aug 11.
6
MicroRNA-205 inhibits the proliferation and invasion of breast cancer by regulating AMOT expression.微小RNA-205通过调节AMOT表达抑制乳腺癌的增殖和侵袭。
Oncol Rep. 2015 Oct;34(4):2163-70. doi: 10.3892/or.2015.4148. Epub 2015 Jul 23.
7
miR-503 suppresses metastasis of hepatocellular carcinoma cell by targeting PRMT1.微小RNA-503通过靶向蛋白精氨酸甲基转移酶1抑制肝癌细胞转移。
Biochem Biophys Res Commun. 2015 Sep 4;464(4):982-987. doi: 10.1016/j.bbrc.2015.06.169. Epub 2015 Jul 7.
8
Up-regulation of miR-877 induced by paclitaxel inhibits hepatocellular carcinoma cell proliferation though targeting FOXM1.紫杉醇诱导的miR-877上调通过靶向FOXM1抑制肝癌细胞增殖。
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1515-24. eCollection 2015.
9
miR-205 regulates A549 cells proliferation by targeting PTEN.微小RNA-205通过靶向磷酸酶和张力蛋白同源物来调节A549细胞的增殖。
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1175-83. eCollection 2015.
10
The expression and clinical significance of serum miR-205 for breast cancer and its role in detection of human cancers.血清miR-205在乳腺癌中的表达及临床意义及其在人类癌症检测中的作用。
Int J Clin Exp Med. 2015 Feb 15;8(2):3034-43. eCollection 2015.