Ibrahim Musab Mohamed, Elsaman Tilal, Al-Nour Mosab Yahya
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omdurman Islamic University, Omdurman, Sudan.
Int J Med Chem. 2018 Jun 12;2018:9139786. doi: 10.1155/2018/9139786. eCollection 2018.
The design, synthesis, and development of novel non-steroidal anti-inflammatory drugs (NSAIDs) with better activity and lower side effects are respectable area of research. Novel Diclofenac Schiff's bases ( and ) were designed and synthesized, and their respective chemical structures were deduced using various spectral tools (IR, H NMR, C NMR, and MS). The compounds were synthesized via Schiff's condensation reaction and their anti-inflammatory activity was investigated applying the Carrageenan-induced paw edema model against Diclofenac as positive control. Percentage inhibition of edema indicated that all compounds were exhibiting a comparable anti-inflammatory activity as Diclofenac. Moreover, the anti-inflammatory activity was supported via virtual screening using molecular docking study. Interestingly compound showed the highest in vivo activity (61.32% inhibition) when compared to standard Diclofenac (51.36% inhibition) as well as the best binding energy score (-10.765) and the virtual screening docking score (-12.142).
设计、合成和开发具有更好活性和更低副作用的新型非甾体抗炎药（NSAIDs）是值得尊敬的研究领域。设计并合成了新型双氯芬酸席夫碱（和），并使用各种光谱工具（红外光谱、氢核磁共振谱、碳核磁共振谱和质谱）推导了它们各自的化学结构。这些化合物通过席夫缩合反应合成，并以双氯芬酸作为阳性对照，应用角叉菜胶诱导的爪肿胀模型研究了它们的抗炎活性。水肿抑制百分比表明，所有化合物均表现出与双氯芬酸相当的抗炎活性。此外，通过分子对接研究进行虚拟筛选支持了抗炎活性。有趣的是，与标准双氯芬酸（抑制率51.36%）相比，化合物表现出最高的体内活性（抑制率61.32%），以及最佳的结合能得分（-10.765）和虚拟筛选对接得分（-12.142）。
