Mashaqi Saif, Steffen Kristine, Crosby Ross, Garcia Luis
Sleep Medicine, Sanford Health.
School of Pharmacy/pharmaceutical Sciences, North Dakota State University.
Cureus. 2018 May 8;10(5):e2593. doi: 10.7759/cureus.2593.
Background Obstructive sleep apnea (OSA) is a common sleep disorder, especially in patients with obesity. Bariatric surgery is an effective tool to reduce weight and treat co-morbid diseases in patients with morbid obesity. One of these disorders is OSA. The most common bariatric procedures currently performed are Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (LSG). Objectives Our study demonstrates that bariatric surgery is a very effective tool to reduce the severity of OSA, if not resolve it. Methods The medical charts of nine patients who had OSA and underwent bariatric surgery (LSG or RYGB) were reviewed and the apnea-hypopnea index (AHI) was compared before and after surgery. The study was conducted at the Sanford sleep center which is affiliated with the University of North Dakota School of Medicine. Results One patient was excluded from the statistical analysis since he was the only male patient, the remaining nine female patients had a significant reduction in AHI after surgery. The mean AHI before surgery was 40 events per hour and seven events per hour after surgery (P 0.004). The mean follow-up with sleep study after surgery was 16 months. The mean reduction in AHI was 80%. There was also an improvement in oxygen saturation (SpO2) before and after surgery (90% and 94% respectively, P 0.008). Conclusion The study confirms the significant reduction in AHI after bariatric surgery in female patients with OSA especially short term (one to two years postoperatively).
阻塞性睡眠呼吸暂停(OSA)是一种常见的睡眠障碍,在肥胖患者中尤为常见。减肥手术是减轻病态肥胖患者体重并治疗其合并症的有效手段。OSA就是其中一种合并症。目前最常用的减肥手术是Roux-en-Y胃旁路术(RYGB)和腹腔镜袖状胃切除术(LSG)。
我们的研究表明,减肥手术是减轻OSA严重程度(即便无法消除)的非常有效的手段。
回顾了9例患有OSA并接受减肥手术(LSG或RYGB)患者的病历,并比较了手术前后的呼吸暂停低通气指数(AHI)。该研究在隶属于北达科他大学医学院的桑福德睡眠中心进行。
1例患者被排除在统计分析之外,因为他是唯一的男性患者,其余9例女性患者术后AHI显著降低。术前平均AHI为每小时40次事件,术后为每小时7次事件(P<0.004)。术后睡眠研究的平均随访时间为16个月。AHI的平均降低幅度为80%。手术前后的血氧饱和度(SpO2)也有所改善(分别为90%和94%,P<0.008)。
该研究证实,减肥手术后,患有OSA的女性患者的AHI显著降低,尤其是在短期(术后1至2年)。