脑脊液非磷酸化 Tau 作为鉴别阿尔茨海默病与克雅氏病的生物标志物。
CSF nonphosphorylated Tau as a biomarker for the discrimination of AD from CJD.
作者信息
Ermann Natalia, Lewczuk Piotr, Schmitz Matthias, Lange Peter, Knipper Tobias, Goebel Stefan, Kornhuber Johannes, Zerr Inga, Llorens Franc
机构信息
Department of Psychiatry and Psychotherapy Universitätsklinikum Erlangen, and Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Germany.
Department of Neurodegeneration Diagnostics Medical University of Białystok Białystok Poland.
出版信息
Ann Clin Transl Neurol. 2018 May 26;5(7):883-887. doi: 10.1002/acn3.584. eCollection 2018 Jul.
Creutzfeldt-Jakob disease and Alzheimer's disease are characterized by the presence of elevated total-Tau cerebrospinal fluid concentrations while the presence of hyperphosphorylated Tau forms in the cerebrospinal fluid is rather a hallmark of Alzheimer's disease. Here we aimed to investigate potential contribution of nonphospho-Tau epitopes (non-P-Tau) in the discrimination between both diseases. Non-P-Tau cerebrospinal fluid concentration was highly increased in Creutzfeldt-Jakob disease ( = 57, 3683 ± 3599 pg/mL) compared to Alzheimer's disease ( = 41, 148 ± 219 pg/mL) and neurological controls ( = 56, 62 ± 40 pg/mL), and significantly improved the proportion of correctly classified patients (99%) compared to that achieved by total-Tau (90%), P-Tau (62%) and 14-3-3 (91%).
克雅氏病和阿尔茨海默病的特征是脑脊液中总 Tau 蛋白浓度升高，而脑脊液中存在过度磷酸化的 Tau 蛋白形式则更是阿尔茨海默病的一个标志。在这里，我们旨在研究非磷酸化 Tau 表位（非 P-Tau）在区分这两种疾病中的潜在作用。与阿尔茨海默病（n = 41，148 ± 219 pg/mL）和神经对照组（n = 56，62 ± 40 pg/mL）相比，克雅氏病（n = 57，3683 ± 3599 pg/mL）中非 P-Tau 脑脊液浓度显著升高，与总 Tau（90%）、P-Tau（62%）和 14-3-3（91%）相比，显著提高了正确分类患者的比例（99%）。
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