• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The Effect of Low-Dose Ketamine in Treating Acute Asthma Attack; a Randomized Clinical Trial.小剂量氯胺酮治疗急性哮喘发作的效果；一项随机临床试验。
Emerg (Tehran). 2018;6(1):e21. Epub 2018 Apr 10.
2
Randomized, double-blind, placebo-controlled trial of intravenous ketamine in acute asthma.静脉注射氯胺酮治疗急性哮喘的随机、双盲、安慰剂对照试验。
Ann Emerg Med. 1996 Feb;27(2):170-5. doi: 10.1016/s0196-0644(96)70319-0.
3
The effects of nebulized ketamine and intravenous magnesium sulfate on corticosteroid resistant asthma exacerbation; a randomized clinical trial.雾化氯胺酮与静脉注射硫酸镁对皮质类固醇抵抗性哮喘急性发作的影响；一项随机临床试验。
Asthma Res Pract. 2021 Nov 30;7(1):15. doi: 10.1186/s40733-021-00081-1.
4
The efficacy of ketamine in pediatric emergency department patients who present with acute severe asthma.氯胺酮在患有急性重症哮喘的儿科急诊科患者中的疗效。
Ann Emerg Med. 2005 Jul;46(1):43-50. doi: 10.1016/j.annemergmed.2005.02.024.
5
The 3Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma.3Mg 试验：静脉或雾化硫酸镁与安慰剂治疗成人急性重度哮喘的随机对照试验。
Health Technol Assess. 2014 Apr;18(22):1-168. doi: 10.3310/hta18220.
6
A randomized clinical trial of magnesium sulphate as a vehicle for nebulized salbutamol in the treatment of moderate to severe asthma attacks.一项关于硫酸镁作为雾化沙丁胺醇载体治疗中度至重度哮喘发作的随机临床试验。
Pulm Pharmacol Ther. 2005;18(6):416-21. doi: 10.1016/j.pupt.2005.03.003.
7
Subcutaneous epinephrine versus nebulized terbutaline in the emergency treatment of asthma.皮下注射肾上腺素与雾化吸入特布他林在哮喘急诊治疗中的比较
Clin Pharm. 1983 Jan-Feb;2(1):45-8.
8
Magnesium bolus or infusion fails to improve expiratory flow in acute asthma exacerbations.大剂量注射或输注镁未能改善急性哮喘加重期的呼气流量。
Chest. 1993 Sep;104(3):831-4. doi: 10.1378/chest.104.3.831.
9
Low-dose ketamine improves pain relief in patients receiving intravenous opioids for acute pain in the emergency department: results of a randomized, double-blind, clinical trial.低剂量氯胺酮可改善急诊科接受静脉注射阿片类药物治疗急性疼痛患者的疼痛缓解情况：一项随机、双盲临床试验的结果
Acad Emerg Med. 2014 Nov;21(11):1193-202. doi: 10.1111/acem.12510.
10
Rapid improvement of peak flow in asthmatic patients treated with parenteral methylprednisolone in the emergency department: A randomized controlled study.
Ann Emerg Med. 1999 May;33(5):487-94. doi: 10.1016/s0196-0644(99)70334-3.

引用本文的文献

1
Ketamine as an Adjunct Therapy in Acute Severe Asthma: An In-Depth Review of Efficacy and Clinical Implications.氯胺酮作为急性重症哮喘的辅助治疗：疗效及临床意义的深入综述
Cureus. 2024 Jun 16;16(6):e62483. doi: 10.7759/cureus.62483. eCollection 2024 Jun.
2
Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model.氯胺酮通过诱导炎症细胞凋亡和激活 Nrf2 通路减轻混合粒细胞性哮喘模型中的气道炎症。
Drug Des Devel Ther. 2022 Dec 28;16:4411-4428. doi: 10.2147/DDDT.S391010. eCollection 2022.
3
Safety and feasibility of continuous ketamine infusion for analgosedation in medical and cardiac ICU patients who received mechanical ventilation support: A retrospective cohort study.接受机械通气支持的内科和心脏重症监护病房患者持续输注氯胺酮进行镇痛镇静的安全性和可行性：一项回顾性队列研究。
PLoS One. 2022 Sep 22;17(9):e0274865. doi: 10.1371/journal.pone.0274865. eCollection 2022.
4
Use of ketamine in patients with refractory severe asthma exacerbations: systematic review of prospective studies.在难治性严重哮喘急性加重患者中使用氯胺酮：前瞻性研究的系统评价。
Eur J Clin Pharmacol. 2022 Oct;78(10):1613-1622. doi: 10.1007/s00228-022-03374-3. Epub 2022 Aug 26.
5
Ketamine use in critically ill patients: a narrative review.危重症患者中氯胺酮的使用：一项叙述性综述。
Rev Bras Ter Intensiva. 2022 Apr-Jun;34(2):287-294. doi: 10.5935/0103-507X.20220027-pt.
6
Salbutamol-induced severe lactic acidosis in acute asthma.沙丁胺醇诱发急性哮喘严重乳酸酸中毒
SAGE Open Med Case Rep. 2020 Oct 28;8:2050313X20969027. doi: 10.1177/2050313X20969027. eCollection 2020.
7
The effects of nebulized ketamine and intravenous magnesium sulfate on corticosteroid resistant asthma exacerbation; a randomized clinical trial.雾化氯胺酮与静脉注射硫酸镁对皮质类固醇抵抗性哮喘急性发作的影响；一项随机临床试验。
Asthma Res Pract. 2021 Nov 30;7(1):15. doi: 10.1186/s40733-021-00081-1.
8
Repurposing Potential of Ketamine: Opportunities and Challenges.氯胺酮的重新利用潜力：机遇与挑战。
Indian J Psychol Med. 2020 Jan 6;42(1):22-29. doi: 10.4103/IJPSYM.IJPSYM_228_19. eCollection 2020 Jan-Feb.
9
Acute Severe Asthma in Adolescent and Adult Patients: Current Perspectives on Assessment and Management.青少年及成年患者的急性重度哮喘：评估与管理的当前观点
J Clin Med. 2019 Aug 22;8(9):1283. doi: 10.3390/jcm8091283.

本文引用的文献

1
A 24-week comparison of low-dose ciclesonide and fluticasone propionate in mild to moderate asthma.轻度至中度哮喘中低剂量昔萘酸沙美特罗与丙酸氟替卡松的 24 周比较。
Respir Med. 2010 Aug;104(8):1121-30. doi: 10.1016/j.rmed.2010.03.032. Epub 2010 Apr 28.
2
The dose-response characteristics of inhaled corticosteroids when used to treat asthma: an overview of Cochrane systematic reviews.吸入性糖皮质激素用于治疗哮喘时的剂量-反应特征：Cochrane系统评价概述
Respir Med. 2006 Aug;100(8):1297-306. doi: 10.1016/j.rmed.2006.04.015. Epub 2006 Jun 23.
3
Ketamine to avoid mechanical ventilation in severe pediatric asthma.氯胺酮可避免重度小儿哮喘患者进行机械通气。
J Emerg Med. 2006 Feb;30(2):163-6. doi: 10.1016/j.jemermed.2005.09.003.
4
The global burden of asthma: executive summary of the GINA Dissemination Committee report.哮喘的全球负担：全球哮喘防治创议传播委员会报告执行摘要
Allergy. 2004 May;59(5):469-78. doi: 10.1111/j.1398-9995.2004.00526.x.
5
Ketamine: its use in the emergency department.氯胺酮：其在急诊科的应用。
Emerg Med (Fremantle). 2003 Apr;15(2):155-9. doi: 10.1046/j.1442-2026.2003.00433.x.
6
Emergency department use of ketamine in pediatric status asthmaticus.急诊科在小儿哮喘持续状态中使用氯胺酮。
J Asthma. 2001 Dec;38(8):657-64. doi: 10.1081/jas-100107543.
7
Does ketamine have a role in managing severe exacerbation of asthma in adults?氯胺酮在治疗成人哮喘严重急性发作中是否有作用？
Pharmacotherapy. 2001 Sep;21(9):1100-6. doi: 10.1592/phco.21.13.1100.34618.
8
Non-compliance amongst adolescents with asthma: listening to what they tell us about self-management.青少年哮喘患者的不依从性：倾听他们关于自我管理的讲述
Fam Pract. 2000 Apr;17(2):134-8. doi: 10.1093/fampra/17.2.134.
9
Randomized, double-blind, placebo-controlled trial of intravenous ketamine in acute asthma.静脉注射氯胺酮治疗急性哮喘的随机、双盲、安慰剂对照试验。
Ann Emerg Med. 1996 Feb;27(2):170-5. doi: 10.1016/s0196-0644(96)70319-0.
10
Use of ketamine in an asthmatic child: a case report.
Anesth Analg. 1971 May-Jun;50(3):420-1.

小剂量氯胺酮治疗急性哮喘发作的效果；一项随机临床试验。

The Effect of Low-Dose Ketamine in Treating Acute Asthma Attack; a Randomized Clinical Trial.

作者信息

Esmailian Mehrdad, Koushkian Esfahani Mahboubeh, Heydari Farhad

机构信息

Emergency Medicine Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Emerg (Tehran). 2018;6(1):e21. Epub 2018 Apr 10.

PMID:30009223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6036522/
Abstract

INTRODUCTION

Efficient treatment of asthma can play an important role in controlling asthma attacks, rapid recovery and decrease of patient mortality. Therefore, in the present study the therapeutic effect of low-dose ketamine is evaluated in patients with acute asthma attack.

METHODS

In the present single-blind, randomized clinical trial with placebo control, the effect of low-dose intravenous ketamine in treating 18 to 85 year-old asthmatic patients who presented to the emergency department was evaluated. Peak expiratory flow rate (PEFR) and the patients' response to treatment were measured before and 1 hour after treatment. Additionally, using SPSS 22.0, effectiveness of ketamine with 0.3, 0.4, and 0.5 mg/kg doses followed by infusion of the same dose during 30 minutes were compared with placebo.

RESULTS

92 patients were enrolled (59.8% female, mean age 48.5 ± 13.9 years). 15 (16.3%) patients were treated with 0.3 mg/kg ketamine, 14 (15.2%) with 0.4 mg/kg, and 16 (17.4%) with 0.5 mg/kg doses. Mean PEFR was 336.2 ± 101.5 liters in the placebo group and 345.8 ± 84.7 liters in the ketamine group before intervention (p = 0.6), while after intervention, they were 352.1 ± 101.2 and 415.8 ± 76.2 liters, respectively (p = 0.001). Ketamine treatment with 0.4 and 0.5 mg/kg doses led to a higher increase in PEFR compared to 0.3mg/kg dose (df: 3, 88; F = 23.8; p < 0.001).

CONCLUSION

It seems that administration of 0.4 - 0.5 mg/kg doses of intravenous ketamine followed by infusion of the same dose during 30 minutes can be effective for rapid recovery of PEFR in patients with mild to moderate asthma.

摘要

引言

有效治疗哮喘对控制哮喘发作、促进患者快速康复及降低死亡率具有重要作用。因此，本研究评估了小剂量氯胺酮对急性哮喘发作患者的治疗效果。

方法

在这项有安慰剂对照的单盲随机临床试验中，评估了小剂量静脉注射氯胺酮对18至85岁到急诊科就诊的哮喘患者的治疗效果。在治疗前及治疗后1小时测量呼气峰值流速（PEFR）及患者的治疗反应。此外，使用SPSS 22.0将0.3、0.4和0.5mg/kg剂量氯胺酮随后在30分钟内输注相同剂量的效果与安慰剂进行比较。

结果

共纳入92例患者（女性占59.8%，平均年龄48.5±13.9岁）。15例（16.3%）患者接受0.3mg/kg氯胺酮治疗，14例（15.2%）接受0.4mg/kg治疗，16例（17.4%）接受0.5mg/kg治疗。干预前，安慰剂组平均PEFR为336.2±101.5升，氯胺酮组为345.8±84.7升（p = 0.6），而干预后，分别为352.1±101.2升和415.8±76.2升（p = 0.001）。与0.3mg/kg剂量相比，0.4和0.5mg/kg剂量的氯胺酮治疗使PEFR升高更显著（自由度：3, 88；F = 23.8；p < 0.001）。

结论

静脉注射0.4 - 0.5mg/kg剂量氯胺酮随后在30分钟内输注相同剂量似乎对轻至中度哮喘患者PEFR的快速恢复有效。