Hamet P, Skuherska R, Pang S C, Tremblay J
Hypertension. 1985 Nov-Dec;7(6 Pt 2):II135-42. doi: 10.1161/01.hyp.7.6_pt_2.ii135.
The increased frequency of hypertension in diabetes and of abnormalities of carbohydrate metabolism in hypertension are now well established. It is conceivable that the high coincidence of the two diseases is based on a common metabolic defect. Studies of platelets permit the evaluation of the stimulatory, phosphoinositol-linked and the inhibitory, cyclic adenosine 3',5'-monophosphate-dependent pathways of cell activation. Furthermore, platelets may be relevant for the development of angiopathy through their contents of growth factors. Abnormalities of platelet aggregation have been demonstrated in hypertension and diabetes. They are accompanied by exaggerated stimulation of adenylate cyclase in hypertension and abnormal activity of cyclic guanosine 3',5'-monophosphate phosphodiesterase in diabetes. Defective function of platelets is also observed in patients and animals when the two diseases are present at the same time. Both increased and decreased aggregation have been described in these two diseases in the literature. The apparent discrepancies may be due to different types of platelet preparation, evaluation of aggregation, evolution of defect with age, and form of the disease. Integrated studies of biochemical mechanisms responsible for cell activation are needed to characterize the exact defect present in diabetes and hypertension in platelets.
糖尿病中高血压发病率的增加以及高血压中碳水化合物代谢异常现象现已得到充分证实。可以想象，这两种疾病的高并发率是基于共同的代谢缺陷。对血小板的研究有助于评估细胞激活的刺激途径（磷酸肌醇连接途径）和抑制途径（环磷酸腺苷依赖性途径）。此外，血小板所含的生长因子可能与血管病变的发展有关。高血压和糖尿病患者均已证实存在血小板聚集异常。高血压患者伴有腺苷酸环化酶的过度刺激，糖尿病患者则伴有环磷酸鸟苷磷酸二酯酶的异常活性。当两种疾病同时存在于患者和动物体内时，也会观察到血小板功能缺陷。文献中描述了这两种疾病中血小板聚集既有增加的情况也有减少的情况。这些明显的差异可能归因于血小板制备的类型不同、聚集评估方法不同、缺陷随年龄的演变以及疾病的形式不同。需要对负责细胞激活的生化机制进行综合研究，以明确糖尿病和高血压患者血小板中存在的确切缺陷。
