Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct, Monash University, Melbourne, Australia.
Nat Med. 2011 Nov 7;17(11):1423-36. doi: 10.1038/nm.2515.
The formation of blood clots--thrombosis--at sites of atherosclerotic plaque rupture is a major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in identifying the pathogenic mechanisms regulating arterial thrombosis has led to the development of newer therapeutics, and there is general anticipation that these treatments will have greater efficacy and improved safety. However, major advances in this field require the identification of specific risk factors for arterial thrombosis in affected individuals and a rethink of the 'one size fits all' approach to antithrombotic therapy.
尽管抗血栓治疗在不断改进，但动脉粥样硬化斑块破裂部位的血栓形成（血栓形成）仍然是一个主要的临床问题。在确定调节动脉血栓形成的发病机制方面取得的进展导致了新型治疗方法的发展，人们普遍期望这些治疗方法具有更高的疗效和更好的安全性。然而，该领域的重大进展需要确定受影响个体中动脉血栓形成的特定危险因素，并重新考虑抗血栓治疗的“一刀切”方法。
