R&D Unit, Vital Beautie Research Division, Amorepacific Corp., Yongin, Korea.
Department of Dermatology, Seoul Paik Hospital, Inje University, Seoul, Korea.
J Cosmet Dermatol. 2019 Jun;18(3):879-884. doi: 10.1111/jocd.12714. Epub 2018 Jul 16.
The safety and wrinkle-reducing effects of multipolydioxanone (PDO) scaffold have been confirmed in animal, and clinical tests for 3 months, but the 12-month outcomes, are unknown.
The safety and efficacy of multi-PDO scaffold were tested in animal models and in humans for 12 months.
In the animal study, a multi-PDO scaffold was implanted into the panniculus carnosus of rat dorsal skin (n = 18) and into the subcutaneous layer of minipig dorsal skin (n = 2) followed by histological staining and analysis. In a human study, a multi-PDO scaffold was implanted deep into the periosteal subcutaneous layer under the wrinkles on the upper lips and forehead, followed by evaluation of clinical changes using digital photography and PRIMOS.
A multi-PDO scaffold was not observed after 6 months in rats and minipigs. However, the newly formed tissues within the hollow body of the scaffolds were maintained for up to 12 months. The enhanced effect on the upper lips and forehead wrinkles lasted up to 12 months without any side effects.
A multi-PDO scaffold represents a new tool to improve upper lips and forehead wrinkles.
多聚二氧环己酮（PDO）支架的安全性和除皱效果已在动物和 3 个月的临床测试中得到证实，但 12 个月的结果尚不清楚。
在动物模型和人体中测试多聚 PD0 支架的安全性和疗效，时间为 12 个月。
在动物研究中，将多聚 PD0 支架植入大鼠背部皮肤的脂肪垫（n=18）和小型猪背部皮肤的皮下层（n=2），然后进行组织学染色和分析。在人体研究中，将多聚 PD0 支架植入上唇和额部皱纹下的骨膜皮下深层，然后使用数字摄影和 PRIMOS 评估临床变化。
在大鼠和小型猪中，多聚 PD0 支架在 6 个月后未被观察到。然而，支架中空体内的新形成组织可维持长达 12 个月。对上唇和额头皱纹的增强效果可持续长达 12 个月，无任何副作用。
多聚 PD0 支架是改善上唇和额头皱纹的一种新工具。
