Shin Jung Jin, Park Tae Jun, Kim Bo Young, Kim Chang Min, Suh Dong Hye, Lee Sang Jun, Moon Hye-Rim, Ryu Hwa Jung
a Department of Dermatology , Korea University College of Medicine , Seoul , Republic of Korea.
b Department of Dermatology , Arumdaun Nara Dermatologic Clinic , Seoul , Republic of Korea.
J Cosmet Laser Ther. 2019;21(3):158-162. doi: 10.1080/14764172.2018.1493511. Epub 2018 Jul 6.
Conventional procedures including botulinum toxin and filler injections have their limitations in improving deep wrinkles and decreasing tissue laxity, and possess the propensity for vascular accidents. Absorbable thread is a recently commercialized field, but there is little evidence on comparative superiority.
We observed the effects of polydiaxanone (PDO) threads with different number of strands in relation to collagen production and histopathology in a rat model.
Dorsal skin of rat was divided into five different compartments and four different PDO threads and monofilament poly-lactic acid (PLA) thread were inserted. Tissue samples were obtained at week 1, 2, and 12 after the procedure for histopathologic review and real-time PCR for quantification of collagen.
Multiple PDO filaments produced more collagen at 2 weeks. Single-stranded PLA thread insertion resulted in more Col1α1 levels than the double PDO thread and also showed the most Col1α3 production at week 2. The amount of collagen showed a sharp decline at week 12. Histologic evaluation showed retained threads surrounded by fibrous capsule-like structure at week 12.
We were able to observe more collagen production in multiple stranded PDO threads compared to a single strand and that increasing number of threads leads to more collagen synthesis.
包括肉毒杆菌毒素和填充剂注射在内的传统方法在改善深层皱纹和减少组织松弛方面存在局限性，且有发生血管意外的倾向。可吸收线是一个最近商业化的领域，但关于其相对优势的证据很少。
我们在大鼠模型中观察了不同股数的聚对二氧环己酮（PDO）线对胶原蛋白生成和组织病理学的影响。
将大鼠背部皮肤分为五个不同区域，插入四种不同的PDO线和单丝聚乳酸（PLA）线。在术后第1、2和12周获取组织样本进行组织病理学检查和实时PCR以定量胶原蛋白。
多股PDO细丝在第2周产生更多胶原蛋白。单丝PLA线插入后第1α1型胶原蛋白水平高于双股PDO线，且在第2周时第1α3型胶原蛋白产量最高。胶原蛋白量在第12周时急剧下降。组织学评估显示在第12周时线被纤维囊状结构包围。
与单股线相比，我们观察到多股PDO线能产生更多胶原蛋白，且线的股数增加会导致更多胶原蛋白合成。
