a Department of Pharmacokinetics , KinderPharm LLC , Exton , PA , USA.
b Department of Pharmacokinetic Sciences , Novartis Institutes for BioMedical Research, Inc , Cambridge , MA , USA.
Drug Metab Rev. 2018 Aug;50(3):398-405. doi: 10.1080/03602532.2018.1484756. Epub 2018 Jul 16.
With the inclusion of mesentery, the total number of human organs has recently increased by one. The mesentery was formerly construed to be a complex, discontinuous anatomical structure simply serving as a support for organs in abdominal cavity. However, recent research has established the mesentery to be a far more simple and unfragmented organ. Newly emerging information on the mesentery has challenged some older pathophysiological concepts. This review briefly discusses the anatomy of the mesentery, historical perspective on the mesentery, embryology, drug metabolizing enzymes and transporters of the mesentery, and the mesentery's role in diseases. The possible impact of the mesentery on absorption, distribution, metabolism, and excretion (ADME) is also discussed.
最近，随着肠系膜的纳入，人类器官的总数增加了一个。肠系膜以前被认为是一种复杂的、不连续的解剖结构，仅仅作为腹腔内器官的支撑物。然而，最近的研究已经确定肠系膜是一个更加简单和完整的器官。肠系膜的新信息挑战了一些旧的病理生理学概念。本文简要讨论了肠系膜的解剖结构、肠系膜的历史观点、胚胎学、肠系膜的药物代谢酶和转运体，以及肠系膜在疾病中的作用。还讨论了肠系膜对吸收、分布、代谢和排泄（ADME）的可能影响。
