Schwartz Christopher J, Hickman Richard, Zhang Xuchen, Galvao Neto Antonio, Adler Esther
1 New York University Medical Center, New York, NY, USA.
2 Columbia University, New York, NY, USA.
Int J Surg Pathol. 2019 Feb;27(1):84-88. doi: 10.1177/1066896918782426. Epub 2018 Jul 16.
Mixed carcinomas in the esophagus are highly uncommon neoplasms that represent a diagnostic challenge on small tissue biopsies. We present a case of a primary mixed sarcomatoid-small cell carcinoma of the esophagus that was diagnosed after repeat sampling of the lesion. The components were morphologically distinct and could be further classified by immunohistochemistry. Next-generation sequencing identified mutations in PIK3CA and CDKN2A. The small cell component morphology was also identified in brain metastasis.
