a Vessel Variations , West Fork , AR , USA.
b Life Sciences Institute , University of Michigan , Ann Arbor , MI , USA.
Autophagy. 2018;14(10):1674-1676. doi: 10.1080/15548627.2018.1493315. Epub 2018 Aug 1.
One of the key features of macroautophagy/autophagy is the dynamic nature of the membrane rearrangements that take place during expansion of the phagophore, the sequestering compartment that matures into an autophagosome. There are various ways to depict this process, but in most cases the method ultimately relies on a two-dimensional medium. Most people working in the field of autophagy realize that the typical 'C'-shaped drawing of a phagophore is meant to represent a cup- or bowl-like structure that exists in the cell in 3 dimensions. However, explaining this concept to a lay person often leads to confusion and misinterpretation. Accordingly, we decided to generate a four-dimensional version of the expanding phagophore as a wood sculpture, that depicts this transient compartment in 3 dimensions over time.
ER: endoplasmic reticulum.
巨自噬/自噬的一个关键特征是吞噬体扩张过程中膜重排的动态性质，吞噬体是成熟自噬体的隔离区。有多种方法可以描述这个过程，但在大多数情况下，该方法最终依赖于二维介质。自噬领域的大多数人都意识到，吞噬体的典型“C”形图旨在表示存在于三维细胞中的杯状或碗状结构。然而，向门外汉解释这个概念往往会导致混淆和误解。因此，我们决定制作一个扩张中的吞噬体的四维版本，作为木雕，随着时间的推移，以三维形式描绘这个短暂的隔室。
ER：内质网。
