心脏通道自身抗体与心源性猝死及其与自身免疫性疾病的关系
Autoantibodies for Cardiac Channels and Sudden Cardiac Death and its Relationship to Autoimmune Disorders.
作者信息
Chera Hymie, Nagar Menachem, Richler Aaron, Pourriahi Mahyar, Al-Sadawi Mohammed, Gunsburg Moshe, Shoenfeld Yehuda, Rosen Yitzhak
机构信息
Division of Cardiovascular Medicine, SUNY Downstate Medical Center, 470 Clarkson Avenue, Brooklyn, NY, 11203, United States.
Division of Cardiovascular Medicine, Cardiac Electrophysiology Unit, Brookdale University Hospital, 1 Brookdale Plaza, Brooklyn, NY 11212, United States.
出版信息
Curr Cardiol Rev. 2019;15(1):49-54. doi: 10.2174/1573403X14666180716095201.
BACKGROUND
Sudden Cardiac Death (SCD) is an unexpected death caused by heart dysfunction. Autoantibodies against cardiac proteins may be potentially involved in the occurrence and progression of cardiac disease and SCD. The first report on the role of autoantibodies in idiopathic dilated cardiomyopathy appeared in the 1980s. In recent years new studies on the effects of the presence of specific autoantibodies and their relationship to ventricular arrhythmias and SCD were published. The purpose of the current mini-review is to analyze the results of the research studies focused on the relationship between anti-cardiomyocyte autoantibodies and SCD with respect to autoimmune disorders.
CONCLUSION
According to our analysis, more research is needed to understand the role of these autoantibodies against cardiac proteins in the SCD pathogenesis, and potentially employ this knowledge for improving prognosis of SCD.
背景
心脏性猝死（SCD）是由心脏功能障碍导致的意外死亡。针对心脏蛋白的自身抗体可能潜在地参与了心脏疾病和SCD的发生与发展。关于自身抗体在特发性扩张型心肌病中作用的首次报道出现在20世纪80年代。近年来，发表了关于特定自身抗体的存在及其与室性心律失常和SCD关系的新研究。本综述的目的是分析针对自身免疫性疾病，聚焦于抗心肌细胞自身抗体与SCD之间关系的研究结果。
结论
根据我们的分析，需要更多研究来了解这些针对心脏蛋白的自身抗体在SCD发病机制中的作用，并有可能利用这一知识改善SCD的预后。
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