Harbor-UCLA Medical Center, 1000 W. Carson St., Torrance, CA 90500, United States.
Harbor-UCLA Medical Center, 1000 W. Carson St., Torrance, CA 90500, United States.
Exp Mol Pathol. 2018 Aug;105(1):150-152. doi: 10.1016/j.yexmp.2018.07.004. Epub 2018 Jul 17.
The nature of the immunologic synapse in autoimmune hepatitis is defined. This process involves the T cell receptor (TCR) which binds to the hepatocyte antigen presenting major histocompatibility complex (MHC) on the plasma membrane. This complex is quickly removed from the liver cell and taken into the T cell cytoplasm to be digested by the lysosome. The liver cell is gradually diminished to the point of its total removal by the lymphocytes binding to it.
自身免疫性肝炎中免疫突触的性质被定义。这个过程涉及 T 细胞受体 (TCR)，它与肝细胞表面的抗原呈递主要组织相容性复合物 (MHC) 结合。这个复合物很快从肝细胞中被移除，并被带入 T 细胞质中，由溶酶体进行消化。随着淋巴细胞与肝细胞的结合，肝细胞逐渐减少，最终被完全清除。
