1 Baker IDI Heart and Diabetes Institute, Melbourne, Australia.
2 Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
Eur J Prev Cardiol. 2018 Aug;25(12):1280-1290. doi: 10.1177/2047487318786585. Epub 2018 Jul 17.
Background Temporal trends in incidence and mortality of cardiovascular disease (CVD) have been well described, with recent data suggesting declining improvements in those aged under 55 years. However, little is known about the combined impact of incidence and mortality trends on disease prevalence, an important indicator of disease burden and cost. We analysed changes in age-specific and age-standardised temporal trends in prevalence and incidence of CVD subtypes. Methods Annual prevalence and incidence rates of coronary heart disease, cerebrovascular disease and peripheral arterial disease for the Western Australian population for 1995-2010 were calculated using data from the Western Australian Data Linkage System. Joinpoint regression analyses were used to identify joinpoints in trends in age-specific and age-standardised annual prevalence and incidence rates for each CVD subtype. Results Between 1995 and 2010, age- and sex-specific incidence and prevalence of the CVD subtypes generally decreased among middle-aged and older adults, but were stable or increased among younger adults. In < 55 year olds, increases in incidence tended to occur from 2003, while increases in prevalence were from 2007/2008. Declines in age-standardised incidence were greater than those in crude incidence, with changes in population structure having a greater impact among men than women. Conclusions The majority of CVDs occurs in older adults. Our findings of generally worsening trends in prevalence in younger adults across most CVD subtypes were in contrast to generally declining trends in older age groups. These data highlight the importance of monitoring prevalence and incidence, particularly in younger adults.
心血管疾病(CVD)的发病率和死亡率的时间趋势已经得到了很好的描述,最近的数据表明,55 岁以下人群的改善情况有所下降。然而,对于发病率和死亡率趋势对疾病流行率的综合影响,即疾病负担和成本的一个重要指标,人们知之甚少。我们分析了 CVD 亚型的年龄特异性和年龄标准化时间趋势的发病率和患病率变化。
使用来自西澳大利亚州数据链接系统的数据,计算了 1995 年至 2010 年西澳大利亚州人群中冠心病、脑血管病和外周动脉疾病的年龄特异性和年龄标准化的年度患病率和发病率。使用 Joinpoint 回归分析确定了每种 CVD 亚型的年龄特异性和年龄标准化的年度患病率和发病率的趋势中的 Joinpoint。
在 1995 年至 2010 年期间,中年和老年人群中 CVD 亚型的年龄和性别特异性发病率和患病率普遍下降,但年轻人群中的发病率和患病率保持稳定或增加。在<55 岁的人群中,发病率的增加趋势始于 2003 年,而患病率的增加则始于 2007/2008 年。年龄标准化发病率的下降大于原始发病率的下降,人口结构的变化对男性的影响大于女性。
大多数 CVD 发生在老年人中。我们发现,大多数 CVD 亚型的年轻成年人的患病率普遍呈恶化趋势,这与老年人群中发病率普遍下降的趋势形成对比。这些数据强调了监测发病率和患病率的重要性,特别是在年轻成年人中。